{"id":"W2146142395","doi":"10.1056/nejmoa1412098","title":"Effect of Mutation Order on Myeloproliferative Neoplasms","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":575,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK Cambridge Institute, University of Cambridge; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Mutation; Myeloproliferative neoplasm; Progenitor cell; Janus kinase 2; Haematopoiesis; Essential thrombocythemia; Cancer research; Germline mutation; Polycythemia vera; Stem cell; Clonogenic assay; Medicine; Biology; Myeloid; Immunology; Myelofibrosis; Genetics; Cell culture; Bone marrow; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548186,0.0003140584,0.00037029,0.0005941633,0.000180004,0.0003808667,0.0001670047,0.0003063015,0.001769104],"category_scores_gemma":[0.001341628,0.0001090187,0.0002126575,0.0002435352,0.0002486989,0.0002611933,0.0002485263,0.0003682492,0.0002823171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465545,"about_ca_system_score_gemma":0.0002424542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002925522,"about_ca_topic_score_gemma":0.0005291939,"domain_scores_codex":[0.9994941,0.0001379095,0.00005424461,0.0001112543,0.0001195473,0.00008305217],"domain_scores_gemma":[0.9976185,0.001097977,0.000544391,0.0001202247,0.0001896,0.0004292977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004632395,0.0004187915,0.614145,0.0001706142,0.0002282784,0.001384774,0.0001879515,0.001298181,0.346924,0.0001961852,0.0002735784,0.03014024],"study_design_scores_gemma":[0.0001115512,0.004182027,0.8140354,0.00004719099,0.000388058,0.009427839,0.0002100942,0.002528913,0.1642327,0.0003635093,0.004437236,0.00003540426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984725,0.0006199091,0.0002225148,0.00002201116,0.000006687472,0.00001164559,0.00009560574,0.0000122766,0.0005368373],"genre_scores_gemma":[0.9993482,0.0001496228,0.0002332239,0.0000209834,0.000007204981,0.000004279848,0.0001058974,0.000007213671,0.0001232878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001769104,"threshold_uncertainty_score":0.005918205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386595181152405,"score_gpt":0.3214936602420776,"score_spread":0.2976277084305535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}