{"id":"W2146153583","doi":"10.1073/pnas.0805239105","title":"Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Neural crest; Biology; Phenotype; MAPK/ERK pathway; Transcription factor; Cell biology; Craniofacial; Effector; DiGeorge syndrome; Signal transduction; Neural fold; Crest; Genetics; Neural plate; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005111644,0.00005023849,0.00007329623,0.00007477047,0.000183299,0.00001018912,0.000228203,0.00005302524,0.000001904032],"category_scores_gemma":[0.0005483466,0.00003810243,0.00002366221,0.0001392229,0.0006815097,0.0000138835,0.0001299216,0.00006704131,1.428432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007704377,"about_ca_system_score_gemma":0.00004679848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005453605,"about_ca_topic_score_gemma":9.036776e-7,"domain_scores_codex":[0.9992253,0.00000530034,0.0001610065,0.0001657476,0.0003168442,0.0001258535],"domain_scores_gemma":[0.9997128,0.0000594131,0.00005303422,0.000004638337,0.0001410113,0.0000291155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002315798,0.00002611752,0.02558949,0.00003823243,0.000004498129,7.112817e-9,0.00008654843,0.000006562789,0.9730154,0.001035604,0.00002851585,0.0001458403],"study_design_scores_gemma":[0.0001791506,0.00007539877,0.07607867,0.00001591178,0.000001735881,0.00000716974,0.00005896798,0.0002780845,0.9215857,0.001543738,0.0001241724,0.00005126897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989566,0.0002291596,4.757985e-7,0.0004268689,0.000002276803,0.000142946,0.000004906397,0.000001745888,0.0002350376],"genre_scores_gemma":[0.9989151,0.000005787134,0.0008936026,0.00007436027,0.00002343733,0.00001758069,3.362494e-7,0.000002769625,0.00006700098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05142969,"threshold_uncertainty_score":0.2511051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06635228674179981,"score_gpt":0.3511618760347503,"score_spread":0.2848095892929505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}