{"id":"W2146200359","doi":"10.1093/annonc/mdu550","title":"A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame","funders":"National Cancer Institute; Moffitt Cancer Center","keywords":"Medicine; Internal medicine; Lung cancer; Hazard ratio; Neutropenia; Clinical endpoint; Oncology; Chemotherapy; Gastroenterology; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001309068,0.0002995608,0.001649681,0.0001633621,0.0001522488,0.00000512064,0.0003228441,0.0001571679,0.00008342847],"category_scores_gemma":[0.000754456,0.0001877365,0.0004266933,0.0003386675,0.0003375136,0.00007049388,0.00009037654,0.0002331906,0.00000191899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004154922,"about_ca_system_score_gemma":0.0005069289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000436293,"about_ca_topic_score_gemma":0.0001641911,"domain_scores_codex":[0.9974542,0.0003944226,0.0009188852,0.0004427953,0.000297365,0.0004923793],"domain_scores_gemma":[0.9966859,0.001045231,0.0007654044,0.0006153187,0.0007261723,0.0001619881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4099067,0.01797535,0.003421332,0.0006066784,0.001064694,0.00002907055,0.01260353,0.00008819204,0.2344822,0.000180412,0.01007182,0.30957],"study_design_scores_gemma":[0.6484593,0.02657133,0.00074144,0.0002802754,0.0003881481,0.0000143703,0.001697258,0.0008764662,0.2954869,0.0002084138,0.02495388,0.000322207],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888943,0.001702716,0.0002296685,0.002797981,0.0005783163,0.004853103,0.00003383478,0.00002580587,0.0008842938],"genre_scores_gemma":[0.9925275,0.001831448,0.0005056193,0.002967917,0.0002093684,0.000713577,0.000007167514,0.00004232322,0.001195008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3092478,"threshold_uncertainty_score":0.7655672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04112178112110001,"score_gpt":0.3901629102489096,"score_spread":0.3490411291278096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}