{"id":"W2146210230","doi":"10.1016/j.ydbio.2014.05.014","title":"Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development","year":2014,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Division of Chemistry; Cancer Research Institute; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Cancer Society Research Institute; National Institutes of Health","keywords":"GLI1; Biology; Hedgehog; Hedgehog signaling pathway; Cell biology; PDGFRA; GLI2; Myofibroblast; Signal transduction; Transcription factor; Cancer research; Downregulation and upregulation; Stromal cell; Gene; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003053653,0.0001687981,0.0001901507,0.00005491485,0.0001011684,0.00001034217,0.0001506527,0.0001377759,0.000009114613],"category_scores_gemma":[0.00007683398,0.0001276317,0.00002566323,0.00008433821,0.0001475281,0.000003146959,0.0001469182,0.00006994802,0.000001787454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002313535,"about_ca_system_score_gemma":0.00005356341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001166817,"about_ca_topic_score_gemma":0.0000345576,"domain_scores_codex":[0.9989269,0.0001762919,0.0002608981,0.0003111479,0.00008716324,0.0002376354],"domain_scores_gemma":[0.9996913,0.0000486212,0.00009780626,0.0001033041,0.00002826794,0.00003070771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000404407,0.00003901837,0.02250201,0.00003558126,0.00003926063,2.914239e-7,0.0005584736,0.000003152093,0.9734596,0.0001175817,0.0002393937,0.002965199],"study_design_scores_gemma":[0.0005424251,0.0001634166,0.04907174,0.00003835901,0.000005730414,0.000007815043,0.0001612911,0.00003905021,0.9453955,0.00004969132,0.004335815,0.0001891208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927794,0.0002511184,0.006358173,0.00006001315,0.00005783241,0.0003128081,0.000007643828,0.000007448378,0.0001656085],"genre_scores_gemma":[0.9961926,0.00001299529,0.003359741,0.00008698224,0.00004484168,0.00006039028,0.0001955406,0.00001164229,0.00003529352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02806405,"threshold_uncertainty_score":0.520467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006887141670257951,"score_gpt":0.218138227598247,"score_spread":0.211251085927989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}