{"id":"W2146255696","doi":"10.1128/aac.00639-12","title":"HIV gp120 H375 Is Unique to HIV-1 Subtype CRF01_AE and Confers Strong Resistance to the Entry Inhibitor BMS-599793, a Candidate Microbicide Drug","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Virology; Biology; In silico; Drug resistance; Monoclonal antibody; Human immunodeficiency virus (HIV); Virus; Lentivirus; Antibody; Genetics; Gene; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420246,0.0002475785,0.0002730898,0.0001694402,0.0003285432,0.0001996219,0.0002061693,0.0002660458,0.001729886],"category_scores_gemma":[0.0003519751,0.00009362074,0.0003184765,0.0002994798,0.0001752654,0.0001065719,0.000141315,0.0003646009,0.0004131731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003450982,"about_ca_system_score_gemma":0.0002881816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007460972,"about_ca_topic_score_gemma":0.008691646,"domain_scores_codex":[0.9998287,0.00001859521,0.0000165052,0.00003858714,0.0000401118,0.00005746648],"domain_scores_gemma":[0.9998285,0.00003173479,0.00005425106,0.00002315632,0.00002528473,0.00003716285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004955251,0.0001736213,0.08042575,0.00008172497,0.00007465723,0.002406071,0.0001452502,0.0003464427,0.8982791,0.0002918442,0.001306092,0.01597399],"study_design_scores_gemma":[0.00009807935,0.00186546,0.8623909,0.00003317708,0.0001025062,0.02819007,0.0003683345,0.001962916,0.09267546,0.0002699752,0.01200428,0.00003884801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978163,0.0002335808,0.0003236024,0.00004680222,0.000008923929,0.00002259524,0.0005657085,0.00001390045,0.0009686562],"genre_scores_gemma":[0.9971228,0.0001033307,0.0007295168,0.0000944971,0.00001096651,0.000009928171,0.001499293,0.000007303427,0.000422308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007460972,"threshold_uncertainty_score":0.01483512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00974606648242984,"score_gpt":0.2522064520912218,"score_spread":0.242460385608792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}