{"id":"W2146285889","doi":"10.1111/pbi.12096","title":"Characterization and downstream mannose phosphorylation of human recombinant α‐<scp>L</scp>‐iduronidase produced in <scp>A</scp>rabidopsis <i>complex glycan‐deficient</i> (<i>cgl</i>) seeds","year":2013,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Michael Smith Health Research BC; Wellcome Trust","keywords":"Glycan; Biology; Recombinant DNA; Biochemistry; Mannose; Enzyme; Chinese hamster ovary cell; Enzyme replacement therapy; Mannose 6-phosphate receptor; Arabidopsis; Mutant; Molecular biology; Glycoprotein; Gene; Lysosome; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002463517,0.0002582746,0.0003087413,0.0002752698,0.0002088315,0.00005652577,0.0003082225,0.0004738441,0.0000103279],"category_scores_gemma":[0.0001570464,0.0002352586,0.00006654809,0.0003238743,0.000194622,0.00002492787,0.00009438691,0.0003987998,0.00001133888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002643796,"about_ca_system_score_gemma":0.00006821839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004921969,"about_ca_topic_score_gemma":0.0000440832,"domain_scores_codex":[0.998322,0.00005922192,0.00057416,0.0004538879,0.0001538151,0.0004369491],"domain_scores_gemma":[0.9989775,0.00004787336,0.0004023422,0.0003460679,0.0001133615,0.0001128932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007545848,0.0002297018,0.009590974,0.00002306998,0.00004454061,0.000006651906,0.000121684,0.000007915536,0.9851717,0.0002144843,0.001172924,0.003408787],"study_design_scores_gemma":[0.0011202,0.0003662977,0.06865236,0.00005559301,0.00004002582,0.000565917,0.0004588294,0.0001604731,0.910468,0.0001854534,0.01782512,0.0001016807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973235,0.0004129929,0.0008114892,0.0004916902,0.0001192055,0.0004504199,0.000224694,0.00003552314,0.0001304511],"genre_scores_gemma":[0.9963611,0.00186296,0.0004565784,0.00009465862,0.00006889189,0.00004559027,0.0008518146,0.00002502553,0.0002333223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07470368,"threshold_uncertainty_score":0.9593568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012343190123348,"score_gpt":0.2158955200427041,"score_spread":0.2057720881414706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}