{"id":"W2146285889","doi":"10.1111/pbi.12096","title":"Characterization and downstream mannose phosphorylation of human recombinant α‐<scp>L</scp>‐iduronidase produced in <scp>A</scp>rabidopsis <i>complex glycan‐deficient</i> (<i>cgl</i>) seeds","year":2013,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Michael Smith Health Research BC; Wellcome Trust","keywords":"Glycan; Biology; Recombinant DNA; Biochemistry; Mannose; Enzyme; Chinese hamster ovary cell; Enzyme replacement therapy; Mannose 6-phosphate receptor; Arabidopsis; Mutant; Molecular biology; Glycoprotein; Gene; Lysosome; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000087379,0.0003760789,0.0001591782,0.0001535829,0.00007575356,0.0001814655,0.0001316556,0.0001760859,0.0004243855],"category_scores_gemma":[0.0001096381,0.0000863709,0.0002861581,0.0001868869,0.0001023976,0.0001081045,0.00009098285,0.0003024176,0.0003802139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319707,"about_ca_system_score_gemma":0.000130103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688445,"about_ca_topic_score_gemma":0.001201131,"domain_scores_codex":[0.9999353,0.000008770512,0.000008116961,0.00002078081,0.0000134618,0.00001356451],"domain_scores_gemma":[0.9999304,0.00001305087,0.0000159996,0.000009906259,0.00001194064,0.00001873531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003963454,0.000006689233,0.0001149899,0.00001426676,0.000002803903,0.00004094411,0.0000104738,0.00002720892,0.9993854,0.00002243102,0.000009597185,0.0003254279],"study_design_scores_gemma":[0.000006764102,0.00009668163,0.006378429,0.000004693004,0.00001415965,0.0002303412,0.00002186177,0.0008256721,0.9910095,0.0000194817,0.00138696,0.000005395693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935071,0.0008059941,0.003248582,0.00004907781,0.00001421646,0.00002596118,0.001045354,0.00003568445,0.001267942],"genre_scores_gemma":[0.9881384,0.0005651989,0.004299112,0.00005137366,0.000007200292,0.00002795706,0.003862133,0.00004115592,0.003007552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688445,"threshold_uncertainty_score":0.003357172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012343190123348,"score_gpt":0.2158955200427041,"score_spread":0.2057720881414706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}