{"id":"W2146368001","doi":"10.1074/jbc.m103270200","title":"The Negative Effects of Bile Acids and Tumor Necrosis Factor-α on the Transcription of Cholesterol 7α-Hydroxylase Gene (CYP7A1) Converge to Hepatic Nuclear Factor-4","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Cholesterol 7 alpha-hydroxylase; Transactivation; Chenodeoxycholic acid; Bile acid; Transcription factor; Psychological repression; G protein-coupled bile acid receptor; Protein kinase A; MAPK/ERK pathway; Chemistry; Biology; Molecular biology; Kinase; Cell biology; Biochemistry; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853858,0.0001591624,0.0004187099,0.00002192091,0.0000750368,0.0000108237,0.0001605312,0.0001139868,0.000103101],"category_scores_gemma":[0.000171295,0.00006908408,0.0002045857,0.0001116334,0.0002035392,0.00002949093,0.00001312084,0.0002907746,0.000001319899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003411379,"about_ca_system_score_gemma":0.00002503394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004137276,"about_ca_topic_score_gemma":8.170706e-7,"domain_scores_codex":[0.9989448,0.00004948384,0.0004449651,0.0001326994,0.0002529058,0.0001751698],"domain_scores_gemma":[0.9989949,0.0002799004,0.0002969169,0.0001607305,0.0001123345,0.0001552094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001234917,0.0001664873,0.00508402,0.0001362851,0.00008197008,0.00003678218,0.0003184902,0.000001373352,0.9924349,0.000008154974,0.00001995486,0.000476629],"study_design_scores_gemma":[0.001112006,0.001119041,0.05768559,0.0003015349,0.00006424941,0.00005321952,0.0002431913,0.00001827076,0.9389069,0.0000942749,0.0003257034,0.00007599493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986303,0.0001808847,0.00006589615,0.0007103848,0.0000836786,0.0002212704,0.0000210666,0.000007113342,0.00007942707],"genre_scores_gemma":[0.9990392,0.0004955209,0.00005968193,0.0002343871,0.00007638601,0.000003702803,0.000001714997,0.00001004983,0.00007933621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05352801,"threshold_uncertainty_score":0.2817167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582323588675328,"score_gpt":0.2326831370551513,"score_spread":0.216859901168398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}