{"id":"W2146377217","doi":"10.1139/y09-076","title":"c-Ski, Smurf2, and Arkadia as regulators of TGF-β signaling: new targets for managing myofibroblast function and cardiac fibrosisThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"SMAD; Mediator; Cardiac fibrosis; Transforming growth factor; Extracellular matrix; Cell biology; Myofibroblast; Transforming growth factor beta; Receptor; Signal transduction; Fibrosis; R-SMAD; Biology; Cancer research; Chemistry; Medicine; Internal medicine; Endoglin; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376134,0.0000882926,0.0005141253,0.0001342921,0.00009586562,0.000001345888,0.0000698443,0.00009111543,0.0002731285],"category_scores_gemma":[0.00004163304,0.0000568346,0.0001185686,0.0002014421,0.0005837422,0.00006371034,0.00002009723,0.0001571233,1.992038e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004343515,"about_ca_system_score_gemma":0.000251832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00269781,"about_ca_topic_score_gemma":0.0008799412,"domain_scores_codex":[0.9991506,0.0001426021,0.0003703617,0.0001121604,0.00009033458,0.0001338913],"domain_scores_gemma":[0.9989343,0.0001335325,0.0005489934,0.00007058627,0.0002107137,0.0001019186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001184376,0.0000215835,0.0164304,0.0002018718,0.000258166,5.532432e-7,0.002862911,0.0005564045,0.9735032,0.00008091921,0.003807169,0.00109243],"study_design_scores_gemma":[0.003867283,0.001907135,0.590075,0.0003781322,0.0009659562,0.00002325053,0.004774033,0.0006346923,0.3954813,0.0009684631,0.0008408719,0.0000838292],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960152,0.001149839,0.000008848785,0.002275874,0.0001739524,0.0002231865,0.00002903248,6.400471e-7,0.0001234404],"genre_scores_gemma":[0.9994012,0.0001284272,0.00006683684,0.0001216263,0.0002391305,1.617818e-7,0.000003166474,0.000004186501,0.00003523978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5780219,"threshold_uncertainty_score":0.4078299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082358938019723,"score_gpt":0.2300440229850994,"score_spread":0.2192204336049022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}