{"id":"W2146391955","doi":"10.1074/jbc.m308917200","title":"Initial Binding of the Broad Spectrum Antiviral Nucleoside Ribavirin to the Hepatitis C Virus RNA Polymerase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Polymerase; RNA polymerase; Ribavirin; Virology; RNA-dependent RNA polymerase; Hepatitis C virus; RNA; Chemistry; Nucleotide; Biology; Molecular biology; DNA; Virus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870272,0.0004640359,0.0006216919,0.0001701598,0.0003070099,0.00054549,0.0003808077,0.0005611471,0.001853584],"category_scores_gemma":[0.0009539161,0.0004830863,0.0002870927,0.0001409473,0.0003438888,0.0005158237,0.0003749613,0.000690552,0.00102236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007003019,"about_ca_system_score_gemma":0.0003877642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693232,"about_ca_topic_score_gemma":0.001127938,"domain_scores_codex":[0.9994717,0.00008087902,0.00002525022,0.0001509959,0.0001789337,0.00009225072],"domain_scores_gemma":[0.999714,0.0001177884,0.00003760249,0.00002818338,0.00006449813,0.00003790337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102086,0.00003065695,0.0007345907,0.0001190814,0.00001807994,0.00008337255,0.00006204798,0.0006990311,0.9933839,0.000357596,0.00009633624,0.004304873],"study_design_scores_gemma":[0.000009177623,0.0002502589,0.005909213,0.00001712667,0.00001440688,0.0001567455,0.00005314948,0.006412262,0.9827247,0.0001966706,0.004238938,0.00001733603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9452579,0.005187779,0.03831207,0.0002377257,0.0001010523,0.0003678514,0.0005150825,0.0004473591,0.009573159],"genre_scores_gemma":[0.984487,0.001546954,0.006413541,0.0001299622,0.00002527291,0.0001296024,0.0003987113,0.00007380219,0.006795133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853584,"threshold_uncertainty_score":0.00620085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990583370718286,"score_gpt":0.3239594861497433,"score_spread":0.2840536524425604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}