{"id":"W2146413301","doi":"10.1128/aac.47.8.2393-2396.2003","title":"Reversal of Mefloquine and Quinine Resistance in <i>Plasmodium falciparum</i> with NP30","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mefloquine; Quinine; Plasmodium falciparum; Verapamil; P-glycoprotein; Pharmacology; Multiple drug resistance; Efflux; Quinidine; Chloroquine; Biology; Malaria; Drug resistance; Virology; Microbiology; Medicine; Immunology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449445,0.0001665554,0.0002366147,0.00008073626,0.0000763585,0.0001524476,0.0001746497,0.0001590964,0.0009765341],"category_scores_gemma":[0.0003017929,0.00008952511,0.0001338997,0.00006680674,0.000168266,0.0001922394,0.0001202822,0.0002518201,0.0002981764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214662,"about_ca_system_score_gemma":0.0001168716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005532037,"about_ca_topic_score_gemma":0.0007229018,"domain_scores_codex":[0.9998386,0.0000495706,0.00001872818,0.00002169517,0.00004570902,0.00002579038],"domain_scores_gemma":[0.9998769,0.00003131679,0.00003259321,0.00002001245,0.0000204876,0.00001876288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009073056,0.00002861124,0.0002146076,0.00002236727,0.000001986197,0.00006879862,0.000008940943,0.00002864728,0.9972981,0.00003552731,0.00002718573,0.002174556],"study_design_scores_gemma":[0.0000236041,0.001267501,0.006884385,0.000004525176,0.000006735045,0.000983478,0.00001291984,0.0004233004,0.9887729,0.00003690745,0.001580102,0.000003637219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972287,0.0007656254,0.0008079566,0.00004450356,0.000006324516,0.00002734322,0.00006985826,0.00003273273,0.00101695],"genre_scores_gemma":[0.9973605,0.0003883119,0.001005535,0.00003424511,0.000006053333,0.0000167882,0.0002134818,0.00001095053,0.0009640767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009765341,"threshold_uncertainty_score":0.003266811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025389932571493,"score_gpt":0.2505462229258313,"score_spread":0.2402923236001164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}