{"id":"W2146441141","doi":"10.1158/1078-0432.ccr-07-5165","title":"Polymorphisms in<i>Cyclooxygenase-2</i>and<i>Epidermal Growth Factor Receptor</i>Are Associated with Progression-Free Survival Independent of K-ras in Metastatic Colorectal Cancer Patients Treated with Single-Agent Cetuximab","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"National Cancer Institute; National Institutes of Health; European Commission; Dhont Family Foundation; University of Southern California","keywords":"Cetuximab; Colorectal cancer; Internal medicine; Epidermal growth factor receptor; Medicine; Irinotecan; Genotype; Oxaliplatin; Oncology; Cancer; Cancer research; Gastroenterology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008893354,0.0003987388,0.001428466,0.0003732707,0.0001892503,0.00001999216,0.0002429374,0.000186663,0.0001745422],"category_scores_gemma":[0.001278861,0.0002563759,0.0001240495,0.001314925,0.001105602,0.0001369953,0.0002642008,0.0009864435,0.000002467522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118738,"about_ca_system_score_gemma":0.0009432556,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.006837442,"about_ca_topic_score_gemma":0.02778548,"domain_scores_codex":[0.9945862,0.0007918723,0.001002975,0.0008621987,0.001855922,0.0009007756],"domain_scores_gemma":[0.996779,0.001160056,0.0003591791,0.00031517,0.0009993981,0.0003871645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01257599,0.00472097,0.9769117,0.00009796007,0.0005929995,0.000435984,0.0008066744,0.000003841224,0.0002438066,0.000002755439,0.0002816636,0.003325654],"study_design_scores_gemma":[0.01995681,0.00780102,0.968316,0.001220674,0.0001041146,0.000006207148,0.0002225188,0.00001890948,0.002015401,0.000009710388,0.00005731274,0.0002712783],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942981,0.00213929,5.630069e-7,0.0008715343,0.0001304876,0.001894561,0.0003909324,0.00003500503,0.0002395072],"genre_scores_gemma":[0.9965788,0.002032135,0.00006239824,0.00008346939,0.00007213969,0.0008780956,0.00005703401,0.00006501601,0.0001709432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02094804,"threshold_uncertainty_score":0.9999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1293416916008951,"score_gpt":0.405005177313535,"score_spread":0.2756634857126399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}