{"id":"W2146441141","doi":"10.1158/1078-0432.ccr-07-5165","title":"Polymorphisms in<i>Cyclooxygenase-2</i>and<i>Epidermal Growth Factor Receptor</i>Are Associated with Progression-Free Survival Independent of K-ras in Metastatic Colorectal Cancer Patients Treated with Single-Agent Cetuximab","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"National Cancer Institute; National Institutes of Health; European Commission; Dhont Family Foundation; University of Southern California","keywords":"Cetuximab; Colorectal cancer; Internal medicine; Epidermal growth factor receptor; Medicine; Irinotecan; Genotype; Oxaliplatin; Oncology; Cancer; Cancer research; Gastroenterology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004402274,0.0002788699,0.0002623354,0.0002620329,0.0001714961,0.0002804392,0.0001756389,0.0003490504,0.001017387],"category_scores_gemma":[0.0009121165,0.0001940403,0.0002705934,0.0002079013,0.0002993545,0.00009710262,0.00009794891,0.0004413133,0.0001263144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752098,"about_ca_system_score_gemma":0.0001819569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028717,"about_ca_topic_score_gemma":0.001307869,"domain_scores_codex":[0.9997811,0.00008216737,0.00001532065,0.00005088064,0.0000385355,0.00003202313],"domain_scores_gemma":[0.999171,0.0002555086,0.0003523726,0.00004551587,0.0000341745,0.0001414253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01213058,0.0003374689,0.9516956,0.00006053759,0.000539986,0.000415689,0.00006632092,0.0005271214,0.02830393,0.00004773866,0.0003225328,0.005552405],"study_design_scores_gemma":[0.0002982453,0.001029579,0.9922819,0.000008254779,0.0002439645,0.001400204,0.0000320279,0.001333516,0.003037927,0.00004615797,0.0002815979,0.000006636344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996231,0.0001545753,0.00006709417,0.00002634511,0.000003667766,0.000004170744,0.00004363245,0.000003655489,0.00007381927],"genre_scores_gemma":[0.9997216,0.0000368045,0.00007132732,0.00001841483,0.00001058316,0.000003654712,0.00007142527,0.000001462187,0.00006469643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028717,"threshold_uncertainty_score":0.003403485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1293416916008951,"score_gpt":0.405005177313535,"score_spread":0.2756634857126399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}