{"id":"W2146460215","doi":"10.1248/cpb.55.511","title":".ALPHA.-Substituted 1-Aryl-3-dimethylaminopropanone Hydrochlorides: Potent Cytotoxins towards Human WiDr Colon Cancer Cells","year":2007,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Dimethylamine; Hydrochloride; Aryl; Adduct; Cytotoxicity; Stereochemistry; Potency; IC50; Tertiary amine; Medicinal chemistry; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008731646,0.0002289232,0.0001332433,0.00009505936,0.00005790935,0.00009813056,0.0001288687,0.0001573543,0.001002427],"category_scores_gemma":[0.0001346366,0.00007264129,0.00008849064,0.0000940688,0.0001066519,0.0001494144,0.00009924704,0.0002150979,0.0004419282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008682492,"about_ca_system_score_gemma":0.00009451019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261935,"about_ca_topic_score_gemma":0.0007126599,"domain_scores_codex":[0.9999489,0.00001068364,0.000005704797,0.000009381727,0.00001220031,0.00001324135],"domain_scores_gemma":[0.999926,0.00001383651,0.0000292972,0.000007417106,0.00001013454,0.00001335864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001683595,0.0000245134,0.0002803676,0.00007104587,0.000004089382,0.00007409298,0.00001817344,0.0001887516,0.9932729,0.00006914206,0.00007541374,0.005753102],"study_design_scores_gemma":[0.00002500034,0.001127695,0.002953065,0.000008590132,0.00001111003,0.0003027133,0.000009942458,0.0002902234,0.9912302,0.0000187721,0.004018345,0.000004279095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989916,0.004236891,0.001685624,0.00006705302,0.0000327766,0.00005498772,0.0003468129,0.00006815943,0.003591651],"genre_scores_gemma":[0.9925068,0.00224821,0.002203851,0.00004080591,0.00001679884,0.00003327405,0.0004614392,0.00001132001,0.002477378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002427,"threshold_uncertainty_score":0.003353477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149920340952179,"score_gpt":0.317723535871977,"score_spread":0.2962243324624552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}