{"id":"W2146460215","doi":"10.1248/cpb.55.511","title":".ALPHA.-Substituted 1-Aryl-3-dimethylaminopropanone Hydrochlorides: Potent Cytotoxins towards Human WiDr Colon Cancer Cells","year":2007,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Dimethylamine; Hydrochloride; Aryl; Adduct; Cytotoxicity; Stereochemistry; Potency; IC50; Tertiary amine; Medicinal chemistry; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003343419,0.0003271639,0.000288918,0.00004079187,0.0001451999,0.00003759793,0.0002345974,0.0003051954,0.0004172426],"category_scores_gemma":[0.00002323183,0.0003016175,0.0001339229,0.0001074129,0.0002673447,0.000003018375,0.0002132483,0.0003199721,0.00003060491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005377493,"about_ca_system_score_gemma":0.00006616719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000631414,"about_ca_topic_score_gemma":0.00001422821,"domain_scores_codex":[0.9981152,0.00002185398,0.000361595,0.0006246208,0.0002484629,0.0006282052],"domain_scores_gemma":[0.9990878,0.00003076567,0.00007712807,0.0002483096,0.00008619087,0.0004698341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003959735,0.00018307,0.00004384045,0.00006787627,0.00009591609,0.00002444021,0.00002672689,0.000002851668,0.9869417,0.0002049707,0.0009840392,0.01102858],"study_design_scores_gemma":[0.001205895,0.0001279487,0.00007912062,0.0000252369,0.00006381824,0.00002000553,0.00001651207,0.00002462641,0.788677,0.0001237198,0.209302,0.0003341405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932093,0.002873906,0.001123493,0.0009265486,0.0003645669,0.0003414572,0.000052409,0.00004325114,0.001065039],"genre_scores_gemma":[0.9941781,0.001483522,0.0004856975,0.002341169,0.0007306231,0.00004871057,0.00008853961,0.00004397298,0.000599701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.208318,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149920340952179,"score_gpt":0.317723535871977,"score_spread":0.2962243324624552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}