{"id":"W2146487747","doi":"10.1038/ncomms5760","title":"Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Blood Cancer UK; Leukaemia and Lymphoma Research; Breast Cancer Campaign; British Heart Foundation; Wellcome Trust","keywords":"Alternative splicing; RNA splicing; Exon; Exonic splicing enhancer; Biology; Splicing factor; Genetics; RNA-binding protein; Exon skipping; Gene; Computational biology; Cell biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003910877,0.0001497097,0.0001759395,0.00006701674,0.0005220594,0.00005761729,0.0005959407,0.0002391106,0.000006712154],"category_scores_gemma":[0.0003988498,0.0001382723,0.0000646845,0.0000962529,0.000475816,0.00001150004,0.0002884409,0.0006884379,0.000003535029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000210335,"about_ca_system_score_gemma":0.00005889347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001474361,"about_ca_topic_score_gemma":0.0009628103,"domain_scores_codex":[0.9989294,0.0002208827,0.0001855729,0.0002759001,0.0001348878,0.0002533494],"domain_scores_gemma":[0.9984879,0.00006474478,0.0000988982,0.001026601,0.0001861288,0.0001357114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003278323,0.0001262059,0.01795766,0.00001597666,0.0001666714,0.000001507163,0.0001920746,0.0000293973,0.9473997,0.03224488,0.0008923193,0.0009407665],"study_design_scores_gemma":[0.01284627,0.002251658,0.2265282,0.0005378902,0.0002627181,0.0001154193,0.001512026,0.02968302,0.4643073,0.00682062,0.2526191,0.002515804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752909,0.002039074,0.008855547,0.001667321,0.00004241673,0.0007916447,0.00004907787,0.0000311941,0.01123282],"genre_scores_gemma":[0.9957251,0.0001300978,0.002914872,0.0004149738,0.0001056515,0.0001251663,0.000100297,0.00001733351,0.0004665282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4830925,"threshold_uncertainty_score":0.563858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012288458342541,"score_gpt":0.2980133489949021,"score_spread":0.2857248906523611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}