{"id":"W2146487747","doi":"10.1038/ncomms5760","title":"Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Blood Cancer UK; Leukaemia and Lymphoma Research; Breast Cancer Campaign; British Heart Foundation; Wellcome Trust","keywords":"Alternative splicing; RNA splicing; Exon; Exonic splicing enhancer; Biology; Splicing factor; Genetics; RNA-binding protein; Exon skipping; Gene; Computational biology; Cell biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282337,0.0003911298,0.0001524966,0.0002076905,0.0002027164,0.0003396677,0.0002209238,0.0001831061,0.001119405],"category_scores_gemma":[0.0001340238,0.0002085173,0.0002191182,0.0001555884,0.0001795608,0.0001943584,0.0002450431,0.0002817803,0.0007678969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003993476,"about_ca_system_score_gemma":0.0002066401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005850546,"about_ca_topic_score_gemma":0.002017976,"domain_scores_codex":[0.9998792,0.00001257952,0.000009233688,0.00004146864,0.00003078815,0.00002680871],"domain_scores_gemma":[0.9998735,0.00001773138,0.00004084415,0.00002376384,0.00001712387,0.00002690435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004779757,0.000003109451,0.0004034393,0.00001089395,0.000003558976,0.00002968124,0.000007892178,0.00003511221,0.9985059,0.00005789836,0.00002220783,0.000872394],"study_design_scores_gemma":[0.00001147386,0.00005703087,0.0127457,0.000003773821,0.00001468963,0.0007006791,0.00002386032,0.00108217,0.982905,0.000091284,0.00235918,0.000005240757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923571,0.001420368,0.004005204,0.00006305121,0.00001286612,0.00001001459,0.0004677655,0.0001450152,0.001518571],"genre_scores_gemma":[0.9929165,0.0004091605,0.002335458,0.00004363595,0.00000622973,0.00001200008,0.0009697768,0.00003990061,0.003267303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119405,"threshold_uncertainty_score":0.003744781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012288458342541,"score_gpt":0.2980133489949021,"score_spread":0.2857248906523611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}