{"id":"W2146496496","doi":"10.1084/jem.20091094","title":"Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification","year":2009,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Immune system; Culprit; Virus; Genome; Virology; Computational biology; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000441234,0.000195679,0.0002590192,0.0004188426,0.0002337386,0.0006929097,0.0003322091,0.0006430307,0.001401684],"category_scores_gemma":[0.001244854,0.0002341126,0.0001167939,0.0003089501,0.0004417121,0.0007979855,0.0004542096,0.0007526908,0.0005117432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002513,"about_ca_system_score_gemma":0.0001639302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004279301,"about_ca_topic_score_gemma":0.0005800682,"domain_scores_codex":[0.9997795,0.00003207718,0.000009016121,0.00007431635,0.0000681167,0.00003690354],"domain_scores_gemma":[0.9996414,0.0001442421,0.00009959254,0.00003352986,0.00003927253,0.00004183681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003676006,0.00005527569,0.01821448,0.0001426635,0.00002441036,0.0001778289,0.0001948467,0.002906875,0.9379973,0.003291779,0.0002961719,0.03633083],"study_design_scores_gemma":[0.00005504605,0.0006319689,0.07919518,0.00008467859,0.0001079626,0.002239844,0.0003592909,0.1143374,0.7849878,0.008822723,0.009108869,0.00006925734],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747737,0.00301898,0.01859858,0.0003112364,0.00003729083,0.00003447595,0.0002099522,0.0001904739,0.002825254],"genre_scores_gemma":[0.9892813,0.0009316085,0.008278494,0.000106132,0.00001563653,0.00002257521,0.0001098336,0.00002544899,0.001228842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401684,"threshold_uncertainty_score":0.004689157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02019623644448775,"score_gpt":0.2861251937431405,"score_spread":0.2659289572986528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}