{"id":"W2146530830","doi":"10.1128/aem.72.1.506-515.2006","title":"Protease Inhibitors Fail To Prevent Pore Formation by the Activated <i>Bacillus thuringiensis</i> Toxin Cry1Aa in Insect Brush Border Membrane Vesicles","year":2006,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Proteases; Biochemistry; Vesicle; EGTA; Protease; Manduca sexta; Brush border; Bacillus thuringiensis; Chemistry; Serine protease; Divalent; Biophysics; Biology; Membrane; Calcium; Enzyme; Bacteria; Insect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112787,0.0003250916,0.0004989278,0.0001245431,0.00008673596,0.0005006526,0.0003137902,0.0003272915,0.0006159096],"category_scores_gemma":[0.0005389115,0.0002308747,0.0003517656,0.0001074471,0.0002027912,0.0003563337,0.0001792499,0.0005365571,0.0003904475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002983914,"about_ca_system_score_gemma":0.0002464057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005963714,"about_ca_topic_score_gemma":0.0006860217,"domain_scores_codex":[0.9996712,0.00006567755,0.00005061479,0.00005453258,0.00009868888,0.00005931385],"domain_scores_gemma":[0.9994611,0.0001983925,0.0001694598,0.00005448172,0.00006109192,0.00005551697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008814689,0.00001807875,0.0001233538,0.0000508588,0.00001004469,0.00002883099,0.00001551588,0.00003422786,0.9989021,0.00006004095,0.00002926793,0.0006396421],"study_design_scores_gemma":[0.00002130415,0.0001680284,0.003046061,0.000008116498,0.00001428357,0.0002011718,0.00001182831,0.0005402581,0.9946227,0.00001982132,0.00134263,0.000003836804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934041,0.003055222,0.002089142,0.0001096821,0.00002508508,0.00003107548,0.000363124,0.00007752383,0.0008450176],"genre_scores_gemma":[0.9910837,0.001716805,0.003426111,0.0001102225,0.00001797339,0.00004725474,0.001131902,0.00006120645,0.002404855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006159096,"threshold_uncertainty_score":0.00216502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002379869873830678,"score_gpt":0.1712022038082192,"score_spread":0.1688223339343885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}