{"id":"W2146538416","doi":"10.1128/jvi.02590-09","title":"HIV-1 Vpr Induces the K48-Linked Polyubiquitination and Proteasomal Degradation of Target Cellular Proteins To Activate ATR and Promote G <sub>2</sub> Arrest","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Ubiquitin; Biology; DDB1; Cell biology; DNA ligase; Mutant; RNA interference; Phosphorylation; Tandem affinity purification; Molecular biology; Biochemistry; DNA; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009633188,0.0003073965,0.00019446,0.0001833748,0.0001299257,0.0003029974,0.0001617081,0.0002365958,0.0009876188],"category_scores_gemma":[0.00006896487,0.0001702319,0.0003018789,0.0001214299,0.0001223124,0.0001258626,0.0001876621,0.0004587673,0.00045995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004041236,"about_ca_system_score_gemma":0.0001049639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258281,"about_ca_topic_score_gemma":0.0007737453,"domain_scores_codex":[0.9998945,0.00001592916,0.000009423199,0.00001754795,0.00001740694,0.00004520397],"domain_scores_gemma":[0.9999484,0.000008246913,0.00001389858,0.00001121978,0.000004121147,0.00001402858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000902346,0.00003329638,0.0001314051,0.00002241093,0.000008170412,0.00008331873,0.0000078152,0.00007126282,0.9984481,0.0001056651,0.00005850778,0.0009397055],"study_design_scores_gemma":[0.00001802566,0.0002217639,0.006060888,0.00000621903,0.00001276598,0.0003565667,0.00001785925,0.0009576812,0.9898527,0.00007006004,0.002421601,0.00000378192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956887,0.001837225,0.0007320032,0.00005226942,0.0000226202,0.00002033884,0.0002522488,0.0000589841,0.001335618],"genre_scores_gemma":[0.9950961,0.0007335534,0.0008444819,0.00006373123,0.00000834514,0.00002039923,0.0005638412,0.00002022779,0.002649274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009876188,"threshold_uncertainty_score":0.003303885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008994287057743612,"score_gpt":0.2350804672678609,"score_spread":0.2260861802101173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}