{"id":"W2146561044","doi":"10.2174/092986612800494020","title":"Proprotein Convertase Subtilisin Kexin9 (PCSK9): A Novel Target For Cholesterol Regulation","year":2012,"lang":"en","type":"review","venue":"Protein and Peptide Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Proprotein convertase; Kexin; LDL receptor; Subtilisin; Cholesterol; Internal medicine; Endocrinology; Lipoprotein; Biology; Chemistry; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001278618,0.0006383077,0.001110067,0.0003216015,0.0001914078,0.0004180914,0.0008410974,0.0002500085,0.00001486632],"category_scores_gemma":[0.0001169019,0.0005599981,0.0003992888,0.0003197896,0.0001161395,0.0008485838,0.0003379429,0.0004052565,0.00003663508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386861,"about_ca_system_score_gemma":0.0001974554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003893874,"about_ca_topic_score_gemma":0.000003851776,"domain_scores_codex":[0.9967868,0.0003978236,0.0007764471,0.0009773497,0.0004540536,0.0006075735],"domain_scores_gemma":[0.9979548,0.0003854168,0.0006003657,0.0007502686,0.00008976141,0.000219391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001339544,0.0000748224,0.000002719545,0.01036117,0.00008981663,0.000002972769,0.0001744115,0.00006003439,0.000267341,0.004575801,0.0003611044,0.9840164],"study_design_scores_gemma":[0.0005783362,0.00007903069,0.00003002044,0.003326442,0.0001336503,0.00006346187,0.000001658717,0.005051227,0.0002006214,0.001194051,0.9885731,0.0007684381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0000514782,0.4264894,0.5673952,0.001096293,0.0002278718,0.004516694,0.00008075676,0.0001113133,0.00003099874],"genre_scores_gemma":[0.0001712828,0.09175042,0.8960522,0.002167594,0.001436596,0.006690979,0.0006022435,0.0002230048,0.0009057056],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.9882119,"threshold_uncertainty_score":0.9996852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07371697270533181,"score_gpt":0.3247627348712113,"score_spread":0.2510457621658795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}