{"id":"W2146565570","doi":"10.1074/jbc.m401686200","title":"Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide-based Inhibitor","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Crystallography; Chemistry; Hydrogen bond; Stereochemistry; Crystal structure; Ligand (biochemistry); Space group; Molecule; X-ray crystallography; Biochemistry; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081507,0.0001223604,0.0004346936,0.0001025161,0.00002586642,0.0000235806,0.0001106009,0.0001163441,0.0004262866],"category_scores_gemma":[0.00004225314,0.00007256063,0.0001358015,0.0004487151,0.0002847378,0.00006284985,0.00002401517,0.0001568407,2.839752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002939212,"about_ca_system_score_gemma":0.00005892246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000140872,"about_ca_topic_score_gemma":0.00001050923,"domain_scores_codex":[0.9990787,0.00003654682,0.0004013375,0.0001634701,0.0001769675,0.0001429864],"domain_scores_gemma":[0.9993404,0.00006007474,0.0003256389,0.00008381929,0.00009757072,0.00009250557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008187875,0.0001360072,0.005321758,0.00002447171,0.00005126802,0.00003249511,0.00002921069,0.0006702231,0.9928613,0.000006611558,0.000007201046,0.00004066569],"study_design_scores_gemma":[0.001839559,0.0008353386,0.05342831,0.00006441321,0.0001746722,0.00004270865,0.00007587597,0.0000564188,0.9431471,0.0001573505,0.00003904866,0.000139227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994023,0.00002688071,0.0003914856,0.00005568659,0.00001933217,0.0000340923,0.00002347753,0.000006200797,0.0000405319],"genre_scores_gemma":[0.9981741,0.000004911716,0.001609756,0.00003580694,0.0001530659,0.000001228354,0.00001641651,0.000003428617,0.000001313748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04971422,"threshold_uncertainty_score":0.4667539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502769673034165,"score_gpt":0.223130695262902,"score_spread":0.2081029985325603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}