{"id":"W2146573356","doi":"10.1111/j.1742-4658.2004.04519.x","title":"Protein kinase Cθ activity is involved in the 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin‐induced signal transduction pathway leading to apoptosis in L‐MAT, a human lymphoblastic T‐cell line","year":2005,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Rottlerin; Protein kinase C; Apoptosis; Signal transduction; Cell biology; Cell culture; Biology; Cytosol; Protein kinase A; Kinase; Molecular biology; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007574,0.0002776785,0.0002564618,0.0002783384,0.0002434048,0.0001208995,0.0003074096,0.0002133969,0.0001104286],"category_scores_gemma":[0.0000629222,0.0002361642,0.000168572,0.0003834212,0.00003608717,0.00003807287,0.000042114,0.0004844209,0.00001886708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535015,"about_ca_system_score_gemma":0.0001520748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004554755,"about_ca_topic_score_gemma":0.0003009817,"domain_scores_codex":[0.9979489,0.0003189313,0.0004948618,0.0004068372,0.0003623519,0.0004681073],"domain_scores_gemma":[0.9992679,0.00001822842,0.0001893217,0.0002727861,0.00008458301,0.0001671767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002190256,0.0003301714,0.0001828338,0.00002660661,0.00001242731,0.00001598379,0.000644784,0.001764646,0.9891792,0.00001346912,0.00009492013,0.007515959],"study_design_scores_gemma":[0.001512063,0.000424281,0.0008777987,0.0001450137,0.00001239216,0.00004663123,0.0001994911,0.0004671925,0.9943396,0.00008460053,0.001594311,0.0002965772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938226,0.0002653639,0.003975203,0.001106536,0.00006713789,0.0005867754,0.000009764741,0.00001203621,0.0001546059],"genre_scores_gemma":[0.9977737,0.00001531066,0.000648984,0.0005443598,0.0007700056,0.00007640998,0.00001566849,0.00003252611,0.0001230333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007219382,"threshold_uncertainty_score":0.9630495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224792628420607,"score_gpt":0.26171394550767,"score_spread":0.2392346826656093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}