{"id":"W2146573356","doi":"10.1111/j.1742-4658.2004.04519.x","title":"Protein kinase Cθ activity is involved in the 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin‐induced signal transduction pathway leading to apoptosis in L‐MAT, a human lymphoblastic T‐cell line","year":2005,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Rottlerin; Protein kinase C; Apoptosis; Signal transduction; Cell biology; Cell culture; Biology; Cytosol; Protein kinase A; Kinase; Molecular biology; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579844,0.000559772,0.0002027512,0.0002781402,0.0003606695,0.0003378512,0.0002138066,0.0003536752,0.001749177],"category_scores_gemma":[0.0001650706,0.0001850393,0.0003494671,0.0003096608,0.0002670504,0.0002362275,0.0001258269,0.0008028658,0.0006165457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009025512,"about_ca_system_score_gemma":0.0007401969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145948,"about_ca_topic_score_gemma":0.001309502,"domain_scores_codex":[0.999801,0.00002484243,0.00001601298,0.0000598527,0.00004035132,0.00005794382],"domain_scores_gemma":[0.9999019,0.00001508282,0.00004042959,0.00001010242,0.00001378214,0.00001862774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003667983,0.00008591419,0.0005254512,0.0001796066,0.00001358389,0.0001029733,0.00001119176,0.0001003708,0.9959847,0.0002255545,0.0001040185,0.00229991],"study_design_scores_gemma":[0.00006863756,0.0003254554,0.02210366,0.00002417899,0.00005285223,0.001069351,0.00004100541,0.001099825,0.9686301,0.0001637063,0.0064101,0.00001121853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611883,0.02658504,0.006560631,0.0006356408,0.000280374,0.00009209796,0.0008771675,0.0001517321,0.003629107],"genre_scores_gemma":[0.9844179,0.009122674,0.001876379,0.0001058204,0.00005440143,0.00007742184,0.001355704,0.00001303211,0.002976616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749177,"threshold_uncertainty_score":0.006548464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224792628420607,"score_gpt":0.26171394550767,"score_spread":0.2392346826656093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}