{"id":"W2146589335","doi":"10.1017/s0031182005008991","title":"Ivermectin imposes selection pressure on P-glycoprotein from <i>Onchocerca volvulus</i>: linkage disequilibrium and genotype diversity","year":2005,"lang":"en","type":"article","venue":"Parasitology","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Onchocerca volvulus; Biology; Linkage disequilibrium; Onchocerciasis; Balancing selection; Ivermectin; Population; Genetic diversity; Population bottleneck; Genetics; Locus (genetics); Genotype; Allele; Immunology; Microsatellite; Zoology; Haplotype; Gene; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707223,0.0001241921,0.000190071,0.000462623,0.0001437714,0.0003194271,0.0001220173,0.0001404332,0.0005310977],"category_scores_gemma":[0.0004035048,0.00007148988,0.00009267874,0.0004597891,0.0002060815,0.0001243895,0.0001429918,0.0001497419,0.00005353956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003519083,"about_ca_system_score_gemma":0.0001162696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003311123,"about_ca_topic_score_gemma":0.003599507,"domain_scores_codex":[0.9998695,0.00003604596,0.000008875419,0.00003848712,0.00002117845,0.00002600516],"domain_scores_gemma":[0.9997646,0.00004845114,0.0001300283,0.000009151603,0.00002008438,0.00002760911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005942826,0.000124648,0.4751657,0.00008641151,0.0001392635,0.0003938854,0.0004587485,0.0005860081,0.4994995,0.000212136,0.0001782872,0.02256111],"study_design_scores_gemma":[0.0000198712,0.0002424664,0.9865789,0.000008528504,0.00002971759,0.000510693,0.0001700427,0.0007212463,0.01073864,0.00006288383,0.0009107091,0.000006276422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997451,0.00005463583,0.00005845012,0.000006250175,5.078394e-7,0.000001978487,0.00004070045,0.000001661976,0.0000908449],"genre_scores_gemma":[0.9995858,0.0000516685,0.0001518475,0.000008307067,0.000001148293,0.000002926835,0.0001262521,0.000001402706,0.0000704932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003311123,"threshold_uncertainty_score":0.006583691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817245120128245,"score_gpt":0.2936446533153061,"score_spread":0.2838274081951779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}