{"id":"W2146610385","doi":"10.1016/s1388-1981(02)00217-2","title":"The atypical interaction of peroxisome proliferator-activated receptor α with liver X receptor α antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7α-hydroxylase gene promoter","year":2002,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"Peroxisome proliferator-activated receptor; Receptor; Chemistry; Peroxisome; Endocrinology; Internal medicine; Molecular biology; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023438,0.0005193155,0.0003289779,0.0004638262,0.000202612,0.0004251583,0.0003175164,0.0003801579,0.002119404],"category_scores_gemma":[0.0004716282,0.000395896,0.0004447482,0.0002490302,0.0005184411,0.0002105373,0.0003264628,0.0008503514,0.0007828022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253564,"about_ca_system_score_gemma":0.0002765373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005160497,"about_ca_topic_score_gemma":0.0007204215,"domain_scores_codex":[0.9994888,0.0001376879,0.00003990513,0.00007407174,0.00007402959,0.0001854964],"domain_scores_gemma":[0.999423,0.0001891521,0.0001170221,0.0001123985,0.00002491431,0.0001335252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003963023,0.00003581182,0.0002151697,0.00002249415,0.000007689314,0.00008702385,0.00001634882,0.00006739802,0.9982332,0.0002232877,0.00002453712,0.0006707267],"study_design_scores_gemma":[0.00004769675,0.0005021679,0.003643186,0.000008972901,0.00002416427,0.0007064056,0.00006499322,0.0007267153,0.9918879,0.0001135616,0.00226724,0.000007147928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944501,0.00136419,0.002004773,0.0001034269,0.00005732909,0.00001446932,0.000147116,0.00005672839,0.001801756],"genre_scores_gemma":[0.9952937,0.0008185703,0.000984407,0.00006594858,0.00002552047,0.00002593837,0.0004172644,0.0000210286,0.002347574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002119404,"threshold_uncertainty_score":0.007090092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013981721751132,"score_gpt":0.2298838580287089,"score_spread":0.2197440408111976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}