{"id":"W2146662482","doi":"10.4049/jimmunol.173.5.2960","title":"Lipid Rafts Mediate Association of LFA-1 and CD3 and Formation of the Immunological Synapse of CTL","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Immunological synapse; Lipid raft; CTL*; Cell biology; T-cell receptor; Synapse; CD3; T cell; Biology; Cell signaling; Signal transduction; Immune system; Immunology; Neuroscience; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001608911,0.0001480872,0.0005642162,0.0001547513,0.0001364218,0.000003903258,0.0003981006,0.0003312812,0.00004159244],"category_scores_gemma":[0.0006706493,0.00008107454,0.0001423865,0.0001668492,0.0008949097,0.0001724926,0.0001516621,0.0004978242,0.000002909062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006054898,"about_ca_system_score_gemma":0.000109578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006495846,"about_ca_topic_score_gemma":0.000007198566,"domain_scores_codex":[0.9976897,0.00100512,0.0009353082,0.00007276193,0.00007864413,0.0002184938],"domain_scores_gemma":[0.9966806,0.0008159875,0.001944476,0.0002617878,0.0002900036,0.000007198493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002492364,0.0001155331,0.001075096,0.00002598168,0.0006413904,4.480416e-7,0.003037436,0.00001587184,0.9884238,0.0006543805,0.00003533935,0.003482361],"study_design_scores_gemma":[0.004254194,0.001666024,0.1164342,0.0001734602,0.0002005026,0.0006411579,0.001437993,8.569299e-7,0.872825,0.001341312,0.0009292633,0.00009612013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567152,0.04120402,0.00009837402,0.001298936,0.0004727181,0.0001538945,0.000009950753,0.000004543709,0.00004238883],"genre_scores_gemma":[0.986102,0.01366546,0.00003794139,0.00005052027,0.00001276953,0.000001552758,0.000002188561,0.000008165742,0.0001193872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1155988,"threshold_uncertainty_score":0.3306124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00678171532950344,"score_gpt":0.2113392928683649,"score_spread":0.2045575775388614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}