{"id":"W2146681227","doi":"10.1371/journal.pone.0141085","title":"Diurnal Glycemic Patterns during an 8-Week Open-Label Proof-of-Concept Trial of Empagliflozin in Type 1 Diabetes","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes Management and Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); University of Toronto; University Health Network; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medtronic; Novo Nordisk; Sanofi; GlaxoSmithKline; Eli Lilly and Company","keywords":"Glycemic; Medicine; Empagliflozin; Type 2 diabetes; Ambulatory; Internal medicine; Diabetes mellitus; Placebo; Insulin; Insulin pump; Area under the curve; Endocrinology; Type 1 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002573071,0.0008103275,0.001341542,0.0002673709,0.0002987071,0.0005069306,0.0003527245,0.0005638613,0.001142709],"category_scores_gemma":[0.001822839,0.000256311,0.0004767674,0.0002333892,0.0003757678,0.0004520982,0.0004039089,0.001095264,0.0002031339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064435,"about_ca_system_score_gemma":0.0003087281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002015286,"about_ca_topic_score_gemma":0.0003129978,"domain_scores_codex":[0.999267,0.0003401573,0.00005092903,0.0001420813,0.0001183815,0.00008130926],"domain_scores_gemma":[0.9989574,0.0002100035,0.0003545849,0.0001272901,0.0001026447,0.0002479787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7577834,0.03531072,0.02670469,0.0005067355,0.001113708,0.0001751749,0.000259886,0.001420963,0.1026878,0.00003839592,0.001146236,0.07285223],"study_design_scores_gemma":[0.07349621,0.6277435,0.2723996,0.00003454267,0.001067957,0.0003429892,0.0001206342,0.003939759,0.01886095,0.0001373587,0.001767588,0.00008889181],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998772,0.0002205089,0.0003722229,0.00003524632,0.00002628683,0.0001835196,0.0001974592,0.00003377817,0.00015898],"genre_scores_gemma":[0.997067,0.0001272764,0.001044887,0.0001247356,0.00007136739,0.0006452628,0.0005845207,0.00001120861,0.0003237788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002573071,"threshold_uncertainty_score":0.01360786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1962976968688941,"score_gpt":0.3423029770747954,"score_spread":0.1460052802059013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}