{"id":"W2146684793","doi":"10.1158/1078-0432.ccr-05-1855","title":"Anti-CD3 × Anti-Epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-Cell Cytolytic Activity to EGFR-Positive Cancers <i>In vitro</i> and in an Animal Model","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Cetuximab; Epidermal growth factor receptor; Cancer research; Pancreatic cancer; EGFR inhibitors; Monoclonal antibody; Cytotoxic T cell; Medicine; In vivo; CD3; Antibody; Cancer; Epidermal growth factor; Immunology; Receptor; Biology; Antigen; In vitro; Internal medicine; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422249,0.0004629013,0.0002525532,0.0001929532,0.0001053897,0.0002271878,0.0001560106,0.0002218921,0.0009115044],"category_scores_gemma":[0.00008079317,0.00009503734,0.0002354028,0.0001167478,0.0001739474,0.0001264572,0.00009539689,0.0006485729,0.0003239577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004149,"about_ca_system_score_gemma":0.0002275336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006135087,"about_ca_topic_score_gemma":0.0009964478,"domain_scores_codex":[0.9998543,0.00002315657,0.00001133739,0.0000331176,0.00003498723,0.00004305851],"domain_scores_gemma":[0.9999217,0.00001761173,0.0000196503,0.00001111002,0.000009651132,0.00002021252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840905,0.000146919,0.0001371655,0.00002678783,0.000006123522,0.00002223094,0.000006883772,0.0001210209,0.9979662,0.00003399581,0.00004575492,0.001303095],"study_design_scores_gemma":[0.00004187017,0.001331037,0.001622369,0.000003881139,0.00001766046,0.000196418,0.000004859148,0.0008581955,0.9952728,0.000009190087,0.0006399205,0.000001694078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958823,0.00066025,0.001699934,0.00004129842,0.00001840065,0.00003782805,0.00009655504,0.00009449977,0.001469022],"genre_scores_gemma":[0.996471,0.0004159278,0.001497367,0.00004087449,0.00001354374,0.00003353665,0.0002448371,0.0000159465,0.001266972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009115044,"threshold_uncertainty_score":0.003049314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1702311512438923,"score_gpt":0.505965953970119,"score_spread":0.3357348027262267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}