{"id":"W2146684793","doi":"10.1158/1078-0432.ccr-05-1855","title":"Anti-CD3 × Anti-Epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-Cell Cytolytic Activity to EGFR-Positive Cancers <i>In vitro</i> and in an Animal Model","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Cetuximab; Epidermal growth factor receptor; Cancer research; Pancreatic cancer; EGFR inhibitors; Monoclonal antibody; Cytotoxic T cell; Medicine; In vivo; CD3; Antibody; Cancer; Epidermal growth factor; Immunology; Receptor; Biology; Antigen; In vitro; Internal medicine; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004961343,0.0005840177,0.001750643,0.001248387,0.0002711927,0.0002065222,0.0007254696,0.0006443388,0.0001977519],"category_scores_gemma":[0.001113408,0.0005656122,0.0002268709,0.00273309,0.001182368,0.0005387428,0.0005534376,0.00388215,0.00009008827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003349229,"about_ca_system_score_gemma":0.004007638,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0197066,"about_ca_topic_score_gemma":0.004647162,"domain_scores_codex":[0.9896778,0.00172526,0.001392815,0.002332668,0.002335051,0.002536409],"domain_scores_gemma":[0.9947122,0.001728541,0.0001722453,0.001020806,0.0009526046,0.001413558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008602826,0.001508145,0.2835777,0.0004359363,0.00003579797,0.0005126086,0.0003064933,0.0002713977,0.6947602,0.00002501168,0.005415576,0.004548358],"study_design_scores_gemma":[0.008169197,0.002689113,0.6990225,0.0009826558,0.00003503657,0.00001534956,0.0002438623,0.01841516,0.2681507,0.00009757449,0.001240287,0.0009385694],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875036,0.001125424,0.00004491007,0.005876692,0.0003261469,0.002695453,0.0004801756,0.00009549132,0.001852128],"genre_scores_gemma":[0.9936588,0.002771319,0.0005476426,0.000497575,0.001276436,0.0003485437,0.00007588387,0.00017131,0.0006525347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4266095,"threshold_uncertainty_score":0.9996795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1702311512438923,"score_gpt":0.505965953970119,"score_spread":0.3357348027262267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}