{"id":"W2146692652","doi":"10.1021/jo500328u","title":"Synthesis of 1,5-Dideoxy-1,5-iminoribitol <i>C</i>-Glycosides through a Nitrone–Olefin Cycloaddition Domino Strategy: Identification of Pharmacological Chaperones of Mutant Human Lysosomal β-Galactosidase","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome Canada; SickKids Foundation","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Nitrone; Cycloaddition; Domino; Mutant; Olefin fiber; Glycoside; Stereochemistry; Combinatorial chemistry; Biochemistry; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009011403,0.0003652214,0.0009137741,0.00004056468,0.000124867,0.00002214744,0.0008482992,0.0002868675,0.003756009],"category_scores_gemma":[0.000735558,0.0002809204,0.0003999042,0.0002417403,0.0005365033,0.0002117558,0.0001119613,0.0004956832,0.000002741685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137522,"about_ca_system_score_gemma":0.0001493946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001906201,"about_ca_topic_score_gemma":0.000001523875,"domain_scores_codex":[0.996622,0.000118031,0.001982591,0.0002677376,0.0006980843,0.0003115827],"domain_scores_gemma":[0.9947727,0.0009787006,0.003061616,0.0006000022,0.0004631531,0.0001237781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000439855,0.0005511237,0.0001983173,0.0007191014,0.0003592142,0.000008173988,0.0003285377,0.0000437361,0.996749,0.00001593254,0.0001874336,0.0003995177],"study_design_scores_gemma":[0.0009005431,0.00005698616,0.0002571307,0.0003527275,0.001007262,0.0002472859,0.001190962,0.00007349116,0.9952231,0.0004045617,0.00004051058,0.0002454503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972875,0.0002382148,0.0001794159,0.000183311,0.0000522663,0.00007176596,0.0001499652,0.00002297774,0.001814621],"genre_scores_gemma":[0.9992224,0.0002204369,0.00007346634,0.00001709537,0.0003163704,0.000006942376,0.00001555419,0.00003931084,0.00008844813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003753267,"threshold_uncertainty_score":0.9999643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543526543599993,"score_gpt":0.2455291598888111,"score_spread":0.2300938944528112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}