{"id":"W2146717458","doi":"10.1007/s10549-008-0128-9","title":"Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients","year":2008,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":339,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Breast cancer; Medicine; Oncology; Chemotherapy; Internal medicine; Mastectomy; Cisplatin; Neoadjuvant therapy; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003053088,0.0001297306,0.0003338849,0.0001480406,0.0002089213,0.0002126993,0.0001079299,0.0002470415,0.0008138299],"category_scores_gemma":[0.001628997,0.00008599697,0.0001435756,0.0001395413,0.000174748,0.0001495987,0.0001439256,0.0002583661,0.0001146253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566745,"about_ca_system_score_gemma":0.0002271642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410948,"about_ca_topic_score_gemma":0.0007977186,"domain_scores_codex":[0.9998136,0.0000806044,0.00002375712,0.00002831748,0.00002625964,0.00002753541],"domain_scores_gemma":[0.9995306,0.0001761298,0.0001336244,0.00001516742,0.00003473808,0.0001098199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01399015,0.0006630771,0.9280468,0.0001362051,0.0001171917,0.001881153,0.0003134863,0.001747641,0.01242012,0.0000523827,0.0007488153,0.03988305],"study_design_scores_gemma":[0.0009250118,0.01409899,0.9630098,0.00005119815,0.0001836043,0.008726724,0.0003050071,0.002004578,0.007874433,0.000107804,0.002690765,0.0000219892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998957,0.0004689504,0.00004984817,0.0000756416,0.000005717277,0.00001475904,0.00005604495,0.00000277695,0.0003692691],"genre_scores_gemma":[0.9994899,0.0001260933,0.00008465014,0.00004942522,0.000008039274,0.00002053006,0.0001470723,9.795485e-7,0.00007324763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008138299,"threshold_uncertainty_score":0.002722561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02742652607060869,"score_gpt":0.3384553332689266,"score_spread":0.3110288071983179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}