{"id":"W2146745046","doi":"10.3389/fgene.2012.00195","title":"Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux","year":2012,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Enhancer; Biology; Transcription factor; Genetics; Chromatin; Euchromatin; Regulatory sequence; Genome; Gene; Heterochromatin; Promoter; Regulation of gene expression; Chromosome conformation capture; Cis-regulatory module; Enhancer RNAs; Computational biology; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000840223,0.0003167155,0.000652048,0.0006018411,0.0008577543,0.002498075,0.0007979209,0.0009768039,0.003367222],"category_scores_gemma":[0.001140032,0.0005018407,0.0002713426,0.0005336201,0.001839323,0.003082259,0.001418382,0.0009960842,0.001186877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008370465,"about_ca_system_score_gemma":0.0003901889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004853984,"about_ca_topic_score_gemma":0.0007195597,"domain_scores_codex":[0.9995802,0.00007969864,0.00001448718,0.0001601284,0.00009462876,0.00007087401],"domain_scores_gemma":[0.9995928,0.0001773412,0.00005900432,0.00004397216,0.00005125778,0.00007563989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002948383,0.00006831612,0.00786682,0.0004689982,0.00004622094,0.0006463709,0.002003656,0.003610659,0.7775942,0.1407785,0.002309022,0.06431231],"study_design_scores_gemma":[0.0002115155,0.0004466446,0.05237434,0.0005780006,0.0001972743,0.002960691,0.004629186,0.03394465,0.1970279,0.4521396,0.2552393,0.0002508715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7699601,0.03286184,0.1390235,0.00971959,0.0006991486,0.00007079984,0.0004226263,0.001320305,0.04592209],"genre_scores_gemma":[0.9565135,0.0137965,0.01718619,0.001551898,0.0006535756,0.00009974832,0.0002611135,0.000319339,0.009618027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003367222,"threshold_uncertainty_score":0.01126444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165076185128574,"score_gpt":0.2197785915548338,"score_spread":0.2081278297035481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}