{"id":"W2146745046","doi":"10.3389/fgene.2012.00195","title":"Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux","year":2012,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Enhancer; Biology; Transcription factor; Genetics; Chromatin; Euchromatin; Regulatory sequence; Genome; Gene; Heterochromatin; Promoter; Regulation of gene expression; Chromosome conformation capture; Cis-regulatory module; Enhancer RNAs; Computational biology; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723859,0.0001825385,0.0001867672,0.0001404421,0.00004872884,0.00001686943,0.000186836,0.0002297248,0.00002914089],"category_scores_gemma":[0.000009914475,0.0002108775,0.00007208486,0.0001065194,0.00004311855,0.000006199602,0.00008593652,0.0001094928,0.000009986523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863652,"about_ca_system_score_gemma":0.00004441779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000356698,"about_ca_topic_score_gemma":0.0000657495,"domain_scores_codex":[0.9988053,0.0000470677,0.000297245,0.0002834446,0.0001037765,0.0004632106],"domain_scores_gemma":[0.9995269,0.000003445957,0.00007989716,0.0002821561,0.0000154993,0.00009212505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003478698,0.00003981075,0.3082198,0.00002611793,0.00001998355,9.578796e-7,0.0004783047,0.0007073935,0.6873953,0.000004692707,0.001011251,0.002061614],"study_design_scores_gemma":[0.00254671,0.0002103517,0.6574451,0.00008177212,0.00003839769,0.00002062434,0.001058623,0.01016385,0.3021721,0.0001105128,0.02507119,0.001080681],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879473,0.008221439,0.002258109,0.0000127035,0.0009143286,0.0001975999,0.00002873242,0.000007869905,0.0004119249],"genre_scores_gemma":[0.9896848,0.00101314,0.008399848,0.00005953018,0.0002107515,0.0000182653,0.0001580258,0.00003987607,0.0004158114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3852231,"threshold_uncertainty_score":0.8599337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165076185128574,"score_gpt":0.2197785915548338,"score_spread":0.2081278297035481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}