{"id":"W2146764867","doi":"10.1172/jci64551","title":"The TGR5 receptor mediates bile acid–induced itch and analgesia","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Health and Medical Research Council; Monash University; U.S. Public Health Service; European Regional Development Fund; Regione Toscana; National Science Foundation; Istituto Italiano di Tecnologia; British Heart Foundation; Northern California Institute for Research and Education; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health","keywords":"G protein-coupled bile acid receptor; Agonist; Medicine; Pharmacology; Bile acid; Receptor; Stimulation; Cholecystokinin; Cholestasis; Chemistry; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001700147,0.0003414357,0.0003194922,0.0001480461,0.0001241358,0.0002296724,0.0001469302,0.0004029811,0.001496977],"category_scores_gemma":[0.0001588121,0.00008935657,0.000472996,0.00007370181,0.000269942,0.0002043938,0.0002367829,0.0004746513,0.0004221605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114172,"about_ca_system_score_gemma":0.0001200319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003915796,"about_ca_topic_score_gemma":0.0005976753,"domain_scores_codex":[0.9998714,0.00003868369,0.00001171838,0.00001713458,0.00001551566,0.00004562354],"domain_scores_gemma":[0.9999217,0.000007875912,0.00002957403,0.000007502043,0.000008399543,0.0000250332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002384016,0.000184001,0.01224756,0.0004999613,0.0001056128,0.002831659,0.0001266498,0.000248546,0.9580066,0.0006135734,0.0009161509,0.02183552],"study_design_scores_gemma":[0.0007979257,0.01129801,0.4583443,0.0003824457,0.0006300673,0.01748806,0.00114834,0.005623524,0.4793718,0.0008210925,0.02402424,0.00007017579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808279,0.01265563,0.0021264,0.0005963787,0.00007155865,0.00006903895,0.0001925673,0.0000982748,0.003362309],"genre_scores_gemma":[0.9965959,0.001842088,0.0004576849,0.0001528261,0.00002754355,0.00001639245,0.000123762,0.000003662463,0.0007800479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496977,"threshold_uncertainty_score":0.005007863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05786368543612671,"score_gpt":0.3450134379749202,"score_spread":0.2871497525387935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}