{"id":"W2146764867","doi":"10.1172/jci64551","title":"The TGR5 receptor mediates bile acid–induced itch and analgesia","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Health and Medical Research Council; Monash University; U.S. Public Health Service; European Regional Development Fund; Regione Toscana; National Science Foundation; Istituto Italiano di Tecnologia; British Heart Foundation; Northern California Institute for Research and Education; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health","keywords":"G protein-coupled bile acid receptor; Agonist; Medicine; Pharmacology; Bile acid; Receptor; Stimulation; Cholecystokinin; Cholestasis; Chemistry; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001670793,0.00009262399,0.0003465332,0.00005041454,0.00009727008,0.00004336401,0.00009216787,0.0001452896,0.00009950835],"category_scores_gemma":[0.001043579,0.00004848979,0.0001500438,0.0001275493,0.0001958102,0.0001846787,0.000008845771,0.0004386354,0.00002982845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001450999,"about_ca_system_score_gemma":0.0001703288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007987172,"about_ca_topic_score_gemma":0.000008321763,"domain_scores_codex":[0.9982291,0.0001054632,0.001068002,0.0001083611,0.000351699,0.0001374049],"domain_scores_gemma":[0.9981459,0.0004361305,0.000572848,0.0001309232,0.0003503595,0.000363883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007145605,0.000301501,0.4278596,0.0001624937,0.0005016762,0.0000477657,0.0008136667,0.000002394196,0.3918336,0.002907255,0.03219644,0.1426591],"study_design_scores_gemma":[0.002946759,0.001084837,0.906044,0.0004182452,0.0002869324,0.00005726138,0.0006710264,0.000325955,0.05760968,0.01889307,0.01148237,0.0001798706],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774519,0.000531878,0.00007818155,0.02077103,0.0007952449,0.000174435,5.871267e-7,0.00001045084,0.0001862626],"genre_scores_gemma":[0.9939304,0.001004765,0.00299383,0.0008621955,0.0008518989,0.000004387136,0.000003945325,0.00001173279,0.000336841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4781844,"threshold_uncertainty_score":0.1977356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05786368543612671,"score_gpt":0.3450134379749202,"score_spread":0.2871497525387935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}