{"id":"W2146771723","doi":"10.1073/pnas.122131099","title":"Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Haematopoiesis; Severe combined immunodeficiency; Nod; Myeloid; Genetic enhancement; Stem cell; Viral vector; CD34; Clonogenic assay; Transgene; Progenitor cell; Cord blood; Virology; Transplantation; Cancer research; Immunology; Cell biology; Cell; Gene; Medicine; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324026,0.0001830776,0.0001423466,0.0001527871,0.0001019384,0.0001930316,0.00006981949,0.000151623,0.001112129],"category_scores_gemma":[0.0000994771,0.00006265281,0.0001649707,0.0000899408,0.0001434569,0.0001020584,0.0001361961,0.0002383973,0.0003085451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203952,"about_ca_system_score_gemma":0.0001244217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522545,"about_ca_topic_score_gemma":0.0004178339,"domain_scores_codex":[0.9999034,0.00001908713,0.00001404941,0.0000171722,0.00002436136,0.00002188239],"domain_scores_gemma":[0.9999506,0.00000957696,0.000009641485,0.00001161056,0.000005484533,0.00001308214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004682803,0.00001349117,0.0002265934,0.00001482493,0.000002605223,0.00004805726,0.00001521065,0.00002805953,0.997531,0.0001618104,0.0000328041,0.001878761],"study_design_scores_gemma":[0.00002377908,0.0003369799,0.002326068,0.000007017014,0.00001650547,0.0008338662,0.0000217672,0.0004968193,0.9893827,0.00008114468,0.006470103,0.000003210944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860193,0.001179812,0.009712291,0.00008425475,0.00002372646,0.0000867451,0.0004726942,0.0000892493,0.002331999],"genre_scores_gemma":[0.9841614,0.0009712706,0.009941079,0.00005314693,0.00001322203,0.00008537666,0.00132767,0.00001493692,0.00343184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112129,"threshold_uncertainty_score":0.003720462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02504897720377349,"score_gpt":0.2883345884168665,"score_spread":0.263285611213093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}