{"id":"W2146771723","doi":"10.1073/pnas.122131099","title":"Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Haematopoiesis; Severe combined immunodeficiency; Nod; Myeloid; Genetic enhancement; Stem cell; Viral vector; CD34; Clonogenic assay; Transgene; Progenitor cell; Cord blood; Virology; Transplantation; Cancer research; Immunology; Cell biology; Cell; Gene; Medicine; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005313575,0.00008598469,0.000109761,0.00007765179,0.0001743814,0.0000139553,0.0003242216,0.00007513386,0.00001795747],"category_scores_gemma":[0.00003558477,0.00006059533,0.0000449742,0.0002689688,0.0007226004,0.00002513488,0.00004965586,0.00007108335,1.43869e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001153191,"about_ca_system_score_gemma":0.00001480066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001831279,"about_ca_topic_score_gemma":7.538947e-7,"domain_scores_codex":[0.9987222,0.000009684026,0.0002206842,0.0002387262,0.0006737829,0.0001349202],"domain_scores_gemma":[0.9995548,0.000008889238,0.0002545498,0.00001161836,0.0001383762,0.00003179203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007970793,0.00004122451,0.001816367,0.00002999099,0.00001899821,3.306609e-9,0.00007128873,0.00009209345,0.9971973,0.00006570405,0.0002111364,0.0003762404],"study_design_scores_gemma":[0.0002886729,0.0006124588,0.002049872,0.00002225884,0.000008851011,0.000008017213,0.00007405132,0.0003309074,0.9961461,0.0003547906,0.00003437557,0.00006957897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987475,0.000378122,0.000002387054,0.0002750788,0.000008197322,0.0001233138,0.00001631578,0.000002949277,0.0004461269],"genre_scores_gemma":[0.9993927,0.00009002208,0.0002754047,0.00004799832,0.00005679958,0.000004568284,5.805087e-7,0.000006030026,0.0001258898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105108,"threshold_uncertainty_score":0.2662451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02504897720377349,"score_gpt":0.2883345884168665,"score_spread":0.263285611213093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}