{"id":"W2146781272","doi":"10.1371/journal.ppat.1003848","title":"DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; University of Texas Health Science Center at San Antonio; National Institutes of Health; Georgia Clinical and Translational Science Alliance","keywords":"TRIF; Inflammation; TLR4; Cell biology; Influenza A virus; S100A9; Damp; Virus; Signal transduction; Chemistry; Virology; Biology; Toll-like receptor; Innate immune system; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146512,0.0003985486,0.0002149396,0.0002040774,0.0001659725,0.0002669112,0.000125609,0.0004093491,0.0009162866],"category_scores_gemma":[0.00008949438,0.0001403195,0.000353285,0.0000838683,0.0002462493,0.0003308765,0.0003378478,0.0004661086,0.0002440757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418382,"about_ca_system_score_gemma":0.0001556363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002939325,"about_ca_topic_score_gemma":0.000367954,"domain_scores_codex":[0.9998815,0.00002767508,0.00001307621,0.00002354782,0.00002160375,0.00003251586],"domain_scores_gemma":[0.999938,0.000004604168,0.00001964459,0.000004329479,0.000009203688,0.00002417527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002433518,0.00003649575,0.001043033,0.000121567,0.00001316802,0.0005001274,0.00002835215,0.00005715659,0.9951637,0.0001236469,0.00007925936,0.002590219],"study_design_scores_gemma":[0.0001237714,0.001169777,0.08612953,0.00006327734,0.0000895267,0.003859284,0.0002304571,0.004655207,0.8947278,0.0005819483,0.008345213,0.00002428482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833624,0.01069998,0.002934332,0.0004660931,0.00009121445,0.00005860975,0.0001793698,0.00007106912,0.002136871],"genre_scores_gemma":[0.9935582,0.002590962,0.00177307,0.00009506518,0.0000232622,0.00002846065,0.0001840568,0.000005265785,0.00174173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009162866,"threshold_uncertainty_score":0.003065228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005753344555760796,"score_gpt":0.2379269648609809,"score_spread":0.2321736203052201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}