{"id":"W2146783779","doi":"10.1074/jbc.m404375200","title":"Disorder in a Target for the Smad2 Mad Homology 2 Domain and Its Implications for Binding and Specificity","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Sick Kids Foundation; Hospital for Sick Children; Washington State University","keywords":"Homology (biology); Computational biology; Genetics; Biology; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277251,0.000155308,0.0002321446,0.0001857659,0.0002216555,0.0002707478,0.0002128395,0.0002828751,0.001527094],"category_scores_gemma":[0.000262991,0.0001093671,0.0002298255,0.0001107306,0.0002623383,0.0002444129,0.000182866,0.0002576362,0.000276828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688027,"about_ca_system_score_gemma":0.0001349969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000609316,"about_ca_topic_score_gemma":0.0007157179,"domain_scores_codex":[0.9998946,0.00001532799,0.000006073495,0.00002421467,0.00003513309,0.00002463726],"domain_scores_gemma":[0.9998374,0.00003217893,0.00004967565,0.00001550472,0.00001970239,0.00004550016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000165637,0.00002655768,0.002484571,0.00004412053,0.00001333644,0.000251947,0.00003074613,0.0004999357,0.9950582,0.0004863237,0.00008658993,0.000852131],"study_design_scores_gemma":[0.00006225905,0.000572694,0.08793659,0.00001702867,0.00006701626,0.003822319,0.0003188674,0.01649653,0.8837615,0.001638544,0.005263037,0.00004349111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961578,0.0004376511,0.002358493,0.0000927069,0.00001563634,0.000007732743,0.00009789736,0.00003531731,0.0007967373],"genre_scores_gemma":[0.9988254,0.00007371332,0.000538627,0.00006211732,0.000005326038,0.000005598807,0.0001271008,0.000008069166,0.0003540425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527094,"threshold_uncertainty_score":0.005108654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384897954209326,"score_gpt":0.2826877961437458,"score_spread":0.2588388166016525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}