{"id":"W2146792403","doi":"10.1186/1471-2199-13-34","title":"Directional telomeric silencing and lack of canonical B1 elements in two silencer Autonomously Replicating Sequences in S. cerevisiae","year":2012,"lang":"en","type":"article","venue":"BMC Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Silencer; Biology; Gene silencing; Telomere; Genetics; Psychological repression; Saccharomyces cerevisiae; Autonomously replicating sequence; Gene; Cell biology; DNA replication; Origin of replication; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005976938,0.0001619455,0.0002513609,0.0001049711,0.00002306797,0.000005073892,0.0001565839,0.0001341251,0.00002412513],"category_scores_gemma":[0.0001778807,0.0001600246,0.00005984943,0.0001694826,0.0001226864,0.000006623477,0.0001844229,0.0001086678,0.000002451691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004462131,"about_ca_system_score_gemma":0.0001372817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003709972,"about_ca_topic_score_gemma":0.0002700716,"domain_scores_codex":[0.9984081,0.0002383363,0.0004455269,0.0004380469,0.0000784916,0.0003914421],"domain_scores_gemma":[0.999406,0.00003272271,0.0001639603,0.0002890294,0.00003321606,0.0000750101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001968093,0.00004584165,0.2458944,0.0000201889,0.00001235676,0.000001503137,0.00004031005,0.00003873616,0.7505033,0.00118777,0.000003245639,0.002232633],"study_design_scores_gemma":[0.0009709055,0.0002424468,0.04871025,0.00006175358,0.00001557718,0.00005766662,0.0001493718,0.000328256,0.9474725,0.0005304804,0.001110824,0.0003499962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937984,0.00258649,0.002747931,0.00002590999,0.0001058494,0.0002268758,0.000009997611,0.000009712893,0.0004888806],"genre_scores_gemma":[0.9852464,0.00009804763,0.01431674,0.0001374171,0.00005967915,0.00004518222,0.00004638102,0.00001650784,0.00003359543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1971841,"threshold_uncertainty_score":0.6525613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630400967533369,"score_gpt":0.3504690614288845,"score_spread":0.3241650517535508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}