{"id":"W2146792947","doi":"10.1093/annonc/mdt132","title":"Expression of both Estrogen Receptor-beta 1 (ER-β1) and its co-regulator Steroid Receptor RNA Activator Protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with Estrogen Receptor-alpha (ER-α)-Negative Early Breast Cancer (EBC)","year":2013,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto; CancerCare Manitoba; Sunnybrook Health Science Centre; University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation","keywords":"Tamoxifen; Estrogen receptor; Breast cancer; Tissue microarray; Hazard ratio; Medicine; Internal medicine; Oncology; Estrogen receptor alpha; Immunohistochemistry; Estrogen; Placebo; Progesterone receptor; Endocrinology; Cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118569,0.0002091866,0.0002890553,0.0005574044,0.0001949356,0.000398855,0.000134728,0.0003372467,0.0009917865],"category_scores_gemma":[0.001162066,0.0001333936,0.000135944,0.0004952595,0.0001853144,0.0002027108,0.0001393222,0.0003738372,0.000187438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490349,"about_ca_system_score_gemma":0.0001216343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004453817,"about_ca_topic_score_gemma":0.0006758657,"domain_scores_codex":[0.9999015,0.00002769892,0.00000903044,0.00001556236,0.00002484796,0.00002137873],"domain_scores_gemma":[0.9996333,0.0001544753,0.0001099821,0.00001370491,0.00003581857,0.0000526521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001155528,0.00007648645,0.9783571,0.00003438594,0.00004717396,0.0003046133,0.00005036438,0.00008203624,0.009512787,0.00003738561,0.0001952779,0.01014696],"study_design_scores_gemma":[0.00002254157,0.000240191,0.9960786,0.000005714699,0.00008232539,0.000967156,0.00008179542,0.0003110426,0.001565189,0.0001008391,0.0005414265,0.000003166904],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972174,0.001713492,0.00009084061,0.0001227795,0.00001403665,0.000004206777,0.0001316668,0.000005799631,0.0006996911],"genre_scores_gemma":[0.998855,0.0004884825,0.0001018225,0.00005382387,0.0000360833,0.000004881593,0.0001817422,0.000002285885,0.0002758826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009917865,"threshold_uncertainty_score":0.003317893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359796895481467,"score_gpt":0.2701196207935026,"score_spread":0.2565216518386879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}