{"id":"W2146792947","doi":"10.1093/annonc/mdt132","title":"Expression of both Estrogen Receptor-beta 1 (ER-β1) and its co-regulator Steroid Receptor RNA Activator Protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with Estrogen Receptor-alpha (ER-α)-Negative Early Breast Cancer (EBC)","year":2013,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto; CancerCare Manitoba; Sunnybrook Health Science Centre; University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation","keywords":"Tamoxifen; Estrogen receptor; Breast cancer; Tissue microarray; Hazard ratio; Medicine; Internal medicine; Oncology; Estrogen receptor alpha; Immunohistochemistry; Estrogen; Placebo; Progesterone receptor; Endocrinology; Cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001966305,0.0004528793,0.0007724263,0.0001238664,0.00009220589,0.00001945807,0.0003280045,0.0007130957,0.0001304096],"category_scores_gemma":[0.00005212316,0.0003589818,0.0001593227,0.0001651431,0.000263061,0.00006986943,0.0001172458,0.0002657844,0.000004901356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005954197,"about_ca_system_score_gemma":0.0002333674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004149633,"about_ca_topic_score_gemma":0.00001424735,"domain_scores_codex":[0.9975748,0.0002664229,0.0005872059,0.0007460692,0.0002898897,0.0005355972],"domain_scores_gemma":[0.9977305,0.0001058694,0.0008790129,0.0003781521,0.0006561501,0.000250296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008654089,0.0007945558,0.09208473,0.00005032277,0.0006197317,6.292454e-7,0.0005138521,0.00001746312,0.8840761,0.00001243897,0.001703043,0.011473],"study_design_scores_gemma":[0.005494469,0.008944366,0.09682266,0.0002922516,0.00003267005,9.436013e-7,0.0001510803,0.00001026826,0.8868372,0.00005025985,0.001018002,0.000345795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923001,0.001709558,0.00001085928,0.0003899823,0.0001129817,0.002978327,0.002435528,0.0000170955,0.00004556333],"genre_scores_gemma":[0.9968237,0.000620906,0.0008402045,0.0001115373,0.0001750501,0.0008179144,0.0004495422,0.0000797816,0.00008133188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01112721,"threshold_uncertainty_score":0.9998862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359796895481467,"score_gpt":0.2701196207935026,"score_spread":0.2565216518386879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}