{"id":"W2146803828","doi":"10.1186/1471-2199-8-96","title":"Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1","year":2007,"lang":"en","type":"article","venue":"BMC Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Leibniz-Gemeinschaft; Natural Sciences and Engineering Research Council of Canada; Centre Hospitalier Universitaire de Québec","keywords":"Poly ADP ribose polymerase; Biology; Polymerase; Molecular biology; Gene expression; Gene; Posttranslational modification; Cell biology; Regulation of gene expression; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004484005,0.0001585791,0.000343555,0.0001278992,0.00004749823,0.000002149595,0.0001490462,0.0002226102,0.0002040802],"category_scores_gemma":[0.00009687863,0.000121207,0.000170603,0.0002533798,0.0003598217,0.00005383784,0.00002526211,0.0001187454,0.000003640692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003153333,"about_ca_system_score_gemma":0.0001500059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001333715,"about_ca_topic_score_gemma":0.00000424983,"domain_scores_codex":[0.9982882,0.0002195651,0.0007126278,0.0002838144,0.0002881605,0.0002076064],"domain_scores_gemma":[0.9984635,0.00009490216,0.0005437815,0.0005159898,0.0003339042,0.00004788681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001456475,0.0001813399,0.001807524,0.00008355957,0.00005497805,0.000001021075,0.0005503342,0.00009263762,0.983347,0.01175764,0.00003419926,0.0006332721],"study_design_scores_gemma":[0.001517598,0.0003869597,0.01524787,0.0001118024,0.00003780934,0.00001567115,0.0000866414,0.0001828154,0.9780357,0.003609515,0.0006650946,0.0001025268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.759842,0.001711083,0.2360874,0.0008373117,0.00007264505,0.0008192918,0.00009415486,0.00002287723,0.0005133291],"genre_scores_gemma":[0.9482799,0.000015358,0.05101716,0.0002078968,0.0001047918,0.00001954205,0.0002987334,0.00002692027,0.00002969923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1884379,"threshold_uncertainty_score":0.494268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565817252046142,"score_gpt":0.3173642269724102,"score_spread":0.2917060544519488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}