{"id":"W2146803828","doi":"10.1186/1471-2199-8-96","title":"Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1","year":2007,"lang":"en","type":"article","venue":"BMC Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Leibniz-Gemeinschaft; Natural Sciences and Engineering Research Council of Canada; Centre Hospitalier Universitaire de Québec","keywords":"Poly ADP ribose polymerase; Biology; Polymerase; Molecular biology; Gene expression; Gene; Posttranslational modification; Cell biology; Regulation of gene expression; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016053,0.0004266923,0.000194865,0.0001393948,0.0001270788,0.0003105439,0.0003016467,0.0002784387,0.001260469],"category_scores_gemma":[0.0001467023,0.0001193732,0.0003050449,0.0001163385,0.000306715,0.0002168068,0.0001720456,0.0007158857,0.0004328082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854535,"about_ca_system_score_gemma":0.00009241329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012954,"about_ca_topic_score_gemma":0.0001110603,"domain_scores_codex":[0.9998038,0.00002947679,0.000020133,0.00007271486,0.00004069259,0.00003321027],"domain_scores_gemma":[0.9998287,0.00002944499,0.0000778925,0.00001819372,0.00002119836,0.00002445775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008213834,0.00002574669,0.0003626676,0.00007318227,0.000005158672,0.000047213,0.000009892485,0.00003925819,0.9980659,0.0000923257,0.00003725795,0.001159477],"study_design_scores_gemma":[0.00001959244,0.0003544252,0.007861483,0.00001649152,0.00002675391,0.0004663228,0.00002709776,0.001045806,0.9874852,0.0001160706,0.002574807,0.000005933538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746912,0.009340776,0.01299211,0.0002278999,0.0001266877,0.00005318096,0.0008240835,0.000143411,0.001600685],"genre_scores_gemma":[0.9884697,0.003539432,0.005364085,0.00007471377,0.00003621401,0.00005223175,0.000724636,0.00002057209,0.001718334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260469,"threshold_uncertainty_score":0.004216671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565817252046142,"score_gpt":0.3173642269724102,"score_spread":0.2917060544519488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}