{"id":"W2146822997","doi":"10.1006/dbio.2000.9847","title":"The NED-8 Conjugating System in Caenorhabditis elegans Is Required for Embryogenesis and Terminal Differentiation of the Hypodermis","year":2000,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Biology; Caenorhabditis elegans; RNA interference; Immunostaining; Cell biology; Embryo; NEDD8; Messenger RNA; RNA; Enzyme; Embryogenesis; Molecular biology; Genetics; Gene; Biochemistry; Immunohistochemistry; Ubiquitin; Immunology; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673464,0.0004615194,0.0002151323,0.0004154351,0.0003050742,0.0004023354,0.0002568252,0.0002875515,0.0007362654],"category_scores_gemma":[0.0001941041,0.0003321752,0.0001898262,0.0001027377,0.0004051389,0.0002846069,0.0002723693,0.0007519481,0.0004975761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000387577,"about_ca_system_score_gemma":0.0003177214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006957196,"about_ca_topic_score_gemma":0.001485456,"domain_scores_codex":[0.9998872,0.00001217602,0.00001267091,0.00003073975,0.00003561761,0.00002155668],"domain_scores_gemma":[0.9997966,0.00002684769,0.0000729523,0.00003540922,0.00001596092,0.00005228105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000932711,0.00001197953,0.0002337621,0.0000155012,0.000002870424,0.000103504,0.000009301629,0.00005113501,0.9975164,0.0003326818,0.00004830569,0.001581355],"study_design_scores_gemma":[0.00001472144,0.00006532085,0.00459337,0.000004990761,0.00001224291,0.000304902,0.00001394988,0.0007710376,0.9908713,0.0001080725,0.003233207,0.000006896405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883242,0.001000937,0.008286961,0.00009201191,0.00006947338,0.00001620099,0.0003305951,0.0003364011,0.001543339],"genre_scores_gemma":[0.9876599,0.0003959999,0.00657057,0.0000419787,0.000009657172,0.00001841534,0.0007906214,0.00008581149,0.004427112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007362654,"threshold_uncertainty_score":0.002812088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008269970287008769,"score_gpt":0.2170803954616554,"score_spread":0.2088104251746466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}