{"id":"W2146833615","doi":"10.1158/0008-5472.can-05-1512","title":"Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in Angiogenesis <i>In vitro</i> : Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Hemopexin; Integrin; Matrix metalloproteinase; Angiogenesis; Disintegrin; Extracellular matrix; Matrix metalloproteinase inhibitor; Collagen receptor; Cell biology; Chemistry; Cell adhesion; Type IV collagen; Vitronectin; Biology; Metalloproteinase; Molecular biology; Biochemistry; Cell; Cancer research; Enzyme; Laminin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009031155,0.0001219467,0.0002202492,0.0001151942,0.00006698992,0.0000200337,0.0001878622,0.0001210818,0.00001432008],"category_scores_gemma":[0.0003842261,0.00009570658,0.0000443546,0.0002757786,0.0003175339,0.00001569834,0.0002664323,0.0002154862,5.44413e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003244196,"about_ca_system_score_gemma":0.00009964533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001403052,"about_ca_topic_score_gemma":0.0007605566,"domain_scores_codex":[0.9986492,0.0002106048,0.0002239497,0.0003386952,0.0002519528,0.0003256286],"domain_scores_gemma":[0.9993444,0.0001150458,0.00005399844,0.0002487162,0.0001646262,0.00007320567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003797479,0.00007282922,0.001803251,0.000100233,0.00001654734,0.000006020759,0.00008023268,0.00001128566,0.9948823,0.0002169305,0.00001105933,0.002419568],"study_design_scores_gemma":[0.0003003746,0.0001336635,0.0004723957,0.0001107562,0.00000530957,0.000007577346,0.001065695,0.00007080418,0.9966924,0.0005896739,0.0004502132,0.0001012019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849504,0.0141144,0.00001807673,0.0004119253,0.00003061105,0.0003343245,0.00003982928,0.00000287687,0.00009760113],"genre_scores_gemma":[0.9984862,0.0008357206,0.0003501206,0.00002080888,0.0001406,0.00008626778,0.000004331017,0.00001587193,0.00006014426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01353578,"threshold_uncertainty_score":0.3902801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258339668651514,"score_gpt":0.3459173249340055,"score_spread":0.3233339282474904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}