{"id":"W2146833615","doi":"10.1158/0008-5472.can-05-1512","title":"Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in Angiogenesis <i>In vitro</i> : Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Hemopexin; Integrin; Matrix metalloproteinase; Angiogenesis; Disintegrin; Extracellular matrix; Matrix metalloproteinase inhibitor; Collagen receptor; Cell biology; Chemistry; Cell adhesion; Type IV collagen; Vitronectin; Biology; Metalloproteinase; Molecular biology; Biochemistry; Cell; Cancer research; Enzyme; Laminin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106457,0.0003581004,0.0001989593,0.00008716829,0.000107455,0.0002508572,0.0001492488,0.0002699608,0.0005966941],"category_scores_gemma":[0.0001514274,0.0000959118,0.000173308,0.00008876092,0.000234648,0.0002121089,0.0001252573,0.0004338113,0.0001924246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803918,"about_ca_system_score_gemma":0.0001669851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028503,"about_ca_topic_score_gemma":0.0005422503,"domain_scores_codex":[0.9998615,0.00003483287,0.00001099239,0.00001805273,0.00002877613,0.00004596746],"domain_scores_gemma":[0.9998841,0.00004237669,0.00003483754,0.000009606931,0.000009786587,0.00001924453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008346035,0.0000237449,0.0001438426,0.00004092946,0.000002287929,0.00002480628,0.000008383836,0.00002711125,0.9990508,0.00005951357,0.00001076555,0.000524269],"study_design_scores_gemma":[0.00001212262,0.0003668689,0.002700463,0.00000353139,0.00001176771,0.0002248702,0.00001164779,0.0005789746,0.995222,0.00003207511,0.0008335946,0.000002149257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924405,0.003358985,0.002998801,0.0000856939,0.00001694651,0.00002937528,0.0001220562,0.00002023432,0.0009275759],"genre_scores_gemma":[0.9918677,0.002010153,0.004835119,0.00005397609,0.00001879424,0.00004222007,0.0003229057,0.000006406333,0.0008427963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005966941,"threshold_uncertainty_score":0.00199616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258339668651514,"score_gpt":0.3459173249340055,"score_spread":0.3233339282474904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}