{"id":"W2146867946","doi":"10.1002/chin.200127064","title":"ChemInform Abstract: Flexible Estrogen Receptor Modulators: Design, Synthesis, and Antagonistic Effects in Human MCF‐7 Breast Cancer Cells.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Chemistry; MCF-7; Estrogen receptor; Breast cancer; Estrogen; Human breast; Combinatorial chemistry; Cancer research; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003963849,0.001039583,0.0007166379,0.0006181531,0.0003204195,0.000567436,0.0006283401,0.0004432808,0.01440319],"category_scores_gemma":[0.000204158,0.0004619798,0.000414113,0.00076734,0.0002123671,0.0005004694,0.0002991006,0.0008512898,0.007092183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004674035,"about_ca_system_score_gemma":0.0005176377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007918099,"about_ca_topic_score_gemma":0.001960779,"domain_scores_codex":[0.9998533,0.00002166532,0.0000117476,0.00002151317,0.00006672225,0.00002503942],"domain_scores_gemma":[0.9999393,0.0000113873,0.000008919715,0.000007920757,0.00001191643,0.00002048693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001753513,0.0002272377,0.0001545471,0.001126536,0.00006579717,0.0002607187,0.00007911579,0.001080259,0.8870578,0.001841812,0.02385875,0.08249406],"study_design_scores_gemma":[0.0004627648,0.001100398,0.0008643317,0.00004542241,0.0001420398,0.0004274268,0.00003077097,0.0007367198,0.8250006,0.0003032662,0.1708451,0.00004118876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4342114,0.1681705,0.1013763,0.005877547,0.003186002,0.002084742,0.07935601,0.01391132,0.1918262],"genre_scores_gemma":[0.5609394,0.1140765,0.06153238,0.002042582,0.0005688739,0.0008124835,0.06094631,0.001202923,0.1978786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01440319,"threshold_uncertainty_score":0.0481835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007410593424363471,"score_gpt":0.2383094406207336,"score_spread":0.2308988471963701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}