{"id":"W2146893766","doi":"10.1158/0008-5472.can-04-3494","title":"Nuclear Factor-κB Induced by Doxorubicin Is Deficient in Phosphorylation and Acetylation and Represses Nuclear Factor-κB–Dependent Transcription in Cancer Cells","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Doxorubicin; Transcription factor; NF-κB; IκBα; Acetylation; Cancer research; IκB kinase; Biology; Anthracycline; Cancer cell; Histone deacetylase; Histone deacetylase inhibitor; Signal transduction; Phosphorylation; Cancer; Histone; Cell biology; Biochemistry; Gene; Breast cancer; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535491,0.0003529657,0.0002392654,0.0001944828,0.0001427458,0.00030486,0.0001510824,0.0001714195,0.001658345],"category_scores_gemma":[0.000126908,0.000231724,0.0001704472,0.0001428041,0.0003148201,0.0001840919,0.0001431502,0.0004344893,0.0007669638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283183,"about_ca_system_score_gemma":0.0002286651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006918108,"about_ca_topic_score_gemma":0.001011667,"domain_scores_codex":[0.9998645,0.00002163402,0.00002179675,0.00003343643,0.00003865282,0.00002003676],"domain_scores_gemma":[0.9998436,0.00001872554,0.00006493968,0.00002483259,0.000009066487,0.00003874686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003229987,0.000009044009,0.0000609818,0.00001460322,0.000001658683,0.00001747361,0.000003062238,0.0000130708,0.9995815,0.00004833862,0.00001274707,0.0002052491],"study_design_scores_gemma":[0.00003141126,0.0001597331,0.005454137,0.000009927627,0.00001126088,0.0004825759,0.00001708568,0.0003624108,0.9900857,0.00006111048,0.003320069,0.000004716124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988135,0.003898255,0.005311292,0.0001505228,0.00006353077,0.00003404744,0.0008327578,0.0001178463,0.001456771],"genre_scores_gemma":[0.9905566,0.001746964,0.002954466,0.00004421744,0.00001201202,0.00003922443,0.001195105,0.00003069045,0.003420693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658345,"threshold_uncertainty_score":0.005547762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.059764238038617,"score_gpt":0.3496399318252232,"score_spread":0.2898756937866063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}