{"id":"W2146893766","doi":"10.1158/0008-5472.can-04-3494","title":"Nuclear Factor-κB Induced by Doxorubicin Is Deficient in Phosphorylation and Acetylation and Represses Nuclear Factor-κB–Dependent Transcription in Cancer Cells","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Doxorubicin; Transcription factor; NF-κB; IκBα; Acetylation; Cancer research; IκB kinase; Biology; Anthracycline; Cancer cell; Histone deacetylase; Histone deacetylase inhibitor; Signal transduction; Phosphorylation; Cancer; Histone; Cell biology; Biochemistry; Gene; Breast cancer; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003677815,0.0001691503,0.0001725699,0.000158654,0.0001102523,0.00007958689,0.0001412227,0.0002539592,0.0002710783],"category_scores_gemma":[0.00003266892,0.000176438,0.00002836952,0.0002170637,0.00009288018,0.00002939966,0.00008868973,0.0003616985,0.000009306607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664597,"about_ca_system_score_gemma":0.00009894537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00295948,"about_ca_topic_score_gemma":0.001556154,"domain_scores_codex":[0.9981607,0.0001571589,0.0002688695,0.0006247397,0.0003797194,0.0004088755],"domain_scores_gemma":[0.9994501,0.00002294115,0.00006152855,0.0002464451,0.000110651,0.0001083118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001884916,0.00006401201,0.002744449,0.00004434295,0.00001151637,0.000001186404,0.002223736,0.0002257057,0.9836793,0.00001190074,0.0004290474,0.01037633],"study_design_scores_gemma":[0.0009268718,0.0001464105,0.009523192,0.00007560971,0.000004175488,8.863061e-7,0.0003457809,0.0003985211,0.9806586,0.00001243666,0.007708525,0.0001989872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947941,0.003979985,0.00001304327,0.0004836974,0.00006894438,0.0004470769,0.00009294255,0.00001212378,0.0001081205],"genre_scores_gemma":[0.9955233,0.003957788,0.00003572068,0.0001321589,0.00008338289,0.0000495776,0.00002273117,0.0000420856,0.0001532222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01017734,"threshold_uncertainty_score":0.7194932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.059764238038617,"score_gpt":0.3496399318252232,"score_spread":0.2898756937866063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}