{"id":"W2146900060","doi":"10.1158/1541-7786.mcr-06-0238","title":"Loss of p53 Expression Correlates with Metastatic Phenotype and Transcriptional Profile in a New Mouse Model of Head and Neck Cancer","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Dental and Craniofacial Research","keywords":"Carcinogenesis; Head and neck squamous-cell carcinoma; Head and neck cancer; Cancer research; Biology; Cancer; Tumor suppressor gene; Phenotype; Metastasis; Primary tumor; Gene; Pathology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005084279,0.0001676094,0.0003953313,0.0003843976,0.00003776601,0.000009226595,0.00008796191,0.0001029333,0.00007576729],"category_scores_gemma":[0.00005086758,0.0001419185,0.00004522097,0.0005334179,0.0003337115,0.00007011624,0.00005618082,0.0004907995,6.068744e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686641,"about_ca_system_score_gemma":0.001136705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004045249,"about_ca_topic_score_gemma":0.002085896,"domain_scores_codex":[0.9979371,0.00006724878,0.0003443735,0.0003879114,0.0008397589,0.0004235437],"domain_scores_gemma":[0.9990785,0.00004635558,0.000079848,0.0002576092,0.0003002667,0.0002374224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002727275,0.0001875874,0.007941958,0.0005057287,0.000101337,0.00007501616,0.001527047,0.003319064,0.9804406,0.000449674,0.00006062693,0.002664152],"study_design_scores_gemma":[0.007457101,0.000839413,0.007449376,0.001521528,0.0001075137,0.00002435513,0.0002242995,0.008022467,0.9737392,0.0003115732,0.0000943499,0.0002088172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976582,0.01495276,0.006908343,0.000329222,0.00001956908,0.0008783065,0.00007655556,0.0000114389,0.0002418206],"genre_scores_gemma":[0.9931839,0.0009704996,0.005231097,0.0000503088,0.00001572849,0.00006985503,0.00001573402,0.00004882218,0.0004141084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01660187,"threshold_uncertainty_score":0.6115234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.060316137658776,"score_gpt":0.3670322236107132,"score_spread":0.3067160859519372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}