{"id":"W2146901830","doi":"10.1093/biostatistics/kxu026","title":"Multiple comparison procedures for neuroimaging genomewide association studies","year":2014,"lang":"en","type":"article","venue":"Biostatistics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; University of California, San Diego; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; F. Hoffmann-La Roche; Medpace; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Wellcome Trust; Synarc; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; National Science Foundation","keywords":"Neuroimaging; Imaging genetics; Univariate; False discovery rate; Computer science; Alzheimer's Disease Neuroimaging Initiative; Multiple comparisons problem; Dimensionality reduction; Genome-wide association study; Brain size; Statistical power; Computational biology; Artificial intelligence; Machine learning; Single-nucleotide polymorphism; Neuroscience; Magnetic resonance imaging; Biology; Multivariate statistics; Medicine; Statistics; Genetics; Gene; Genotype; Mathematics; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0004313058,0.000115802,0.0002085642,0.0000261863,0.000144529,0.00001603979,0.00009031414,0.00009776873,0.000001518985],"category_scores_gemma":[0.01420033,0.000114082,0.00005024489,0.00004052021,0.00003242735,0.000001468241,0.00004950224,0.00004645661,0.000007415411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004097455,"about_ca_system_score_gemma":0.00003975583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007450411,"about_ca_topic_score_gemma":0.00009787112,"domain_scores_codex":[0.9990538,0.00009024058,0.0002742322,0.0002460378,0.00007610203,0.0002596227],"domain_scores_gemma":[0.9987506,0.0005695962,0.0002340661,0.0001472782,0.0002550796,0.00004343045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003753817,0.00006816727,0.7596996,0.00009572175,0.0001997253,1.865774e-7,0.000177835,0.0008481422,0.03432302,0.0007804967,0.1980958,0.005673798],"study_design_scores_gemma":[0.00202567,0.0008888318,0.4897586,0.00002357703,0.0001914016,0.000004061652,0.0005294672,0.0287551,0.008967101,0.004062353,0.4641142,0.0006796853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5484458,0.001742406,0.4452849,0.002197187,0.0009505617,0.0006411397,0.0003393577,0.00004758499,0.0003510457],"genre_scores_gemma":[0.9477929,0.0001684864,0.0498687,0.0008629338,0.0003474993,0.00004879386,0.0002901298,0.00001947302,0.000601058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3993472,"threshold_uncertainty_score":0.9941035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238930918415187,"score_gpt":0.3310335732112797,"score_spread":0.2986442640271278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}