{"id":"W2146915953","doi":"10.1158/1078-0432.ccr-11-3085","title":"Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; University of Alberta; Alberta Health Services","funders":"","keywords":"Multiple myeloma; Oncolytic virus; Bone marrow; Population; Ex vivo; Cancer research; Haematopoiesis; In vivo; Medicine; Stem cell; Immunology; Biology; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223277,0.0003330098,0.000237465,0.0002704309,0.0001358432,0.0004694059,0.0002934159,0.0004475123,0.001536806],"category_scores_gemma":[0.00008498519,0.00008206061,0.0003006915,0.0001573566,0.0002956305,0.0002378846,0.0002124449,0.0007505682,0.0003142168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257699,"about_ca_system_score_gemma":0.0002596014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357385,"about_ca_topic_score_gemma":0.0005933563,"domain_scores_codex":[0.9999003,0.00001922404,0.000004709806,0.0000165227,0.00003594224,0.00002315015],"domain_scores_gemma":[0.9999524,0.00001178268,0.00001449657,0.000006378864,0.000004940715,0.00001002539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006562759,0.0002803807,0.000654211,0.0003201187,0.00003217312,0.000237417,0.00003881718,0.0005409791,0.9623799,0.001447535,0.0005724877,0.0328399],"study_design_scores_gemma":[0.0003258471,0.007535008,0.004216223,0.0001647327,0.0001985574,0.002426644,0.00008247919,0.002341781,0.9271035,0.0007739455,0.05481083,0.00002049712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8427404,0.1251668,0.01892885,0.001941503,0.0005400396,0.0002841743,0.0006216576,0.0003455684,0.009431046],"genre_scores_gemma":[0.9632418,0.02704677,0.005143527,0.0001904841,0.000101283,0.00008600378,0.0004675525,0.0000238083,0.003698793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536806,"threshold_uncertainty_score":0.005141139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2658909137045665,"score_gpt":0.5385767344523856,"score_spread":0.2726858207478192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}