{"id":"W2146943626","doi":"10.1186/1742-4690-11-41","title":"Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Aids Fonds; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Antigenicity; Trimer; Epitope; Immunogen; Chemistry; Glycoprotein; Gp41; Protein subunit; Antibody; Glycan; Plasma protein binding; Protein structure; Biochemistry; Biology; Dimer; Immunology; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002371205,0.0002742812,0.0006170683,0.0003860092,0.0002880116,0.00002225671,0.000163766,0.0002503691,0.00007323352],"category_scores_gemma":[0.00008676302,0.0002392891,0.00006716159,0.0001692382,0.000460448,0.0000991768,0.0002337497,0.0003132261,0.0000747009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003695002,"about_ca_system_score_gemma":0.00004090825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759227,"about_ca_topic_score_gemma":0.00004760922,"domain_scores_codex":[0.9980502,0.0003881825,0.0003314211,0.0004909733,0.00005367479,0.0006855588],"domain_scores_gemma":[0.9992054,0.0002638524,0.0001391044,0.0002408883,0.0000479436,0.0001028539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004598692,0.000113414,0.1033481,0.00007827111,0.000305726,0.000007929752,0.000890962,0.000003364274,0.89066,0.0003285349,0.0003452459,0.003458647],"study_design_scores_gemma":[0.01040419,0.006435113,0.3233254,0.0001493433,0.0002697369,0.0001538814,0.0008212787,0.00009365195,0.638114,0.0001064219,0.01926014,0.0008668112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971296,0.0008935211,0.000468137,0.0003363726,0.0002183956,0.0005433075,0.00005880426,0.0000378612,0.0003139526],"genre_scores_gemma":[0.9982192,0.0003259459,0.0002759228,0.00006161078,0.00003067207,0.00004656087,0.0001299986,0.00002544475,0.0008846713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2525459,"threshold_uncertainty_score":0.9757925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443357038737107,"score_gpt":0.2475113739447813,"score_spread":0.2330778035574102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}