{"id":"W2146943626","doi":"10.1186/1742-4690-11-41","title":"Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Aids Fonds; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Antigenicity; Trimer; Epitope; Immunogen; Chemistry; Glycoprotein; Gp41; Protein subunit; Antibody; Glycan; Plasma protein binding; Protein structure; Biochemistry; Biology; Dimer; Immunology; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004114535,0.0003952663,0.0001887793,0.0002406477,0.0001131363,0.0003389827,0.0002920946,0.0003803701,0.001223488],"category_scores_gemma":[0.0004429646,0.0001867786,0.0002991171,0.0001307334,0.0001846308,0.0001938587,0.0002512277,0.0006461916,0.0002278948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174183,"about_ca_system_score_gemma":0.0001362794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004633123,"about_ca_topic_score_gemma":0.0004059484,"domain_scores_codex":[0.9995235,0.00008125625,0.00003092784,0.00008839557,0.0001321615,0.0001437692],"domain_scores_gemma":[0.9996555,0.0001495731,0.00003343999,0.0000393389,0.00006047364,0.00006165673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001487364,0.00005356723,0.0004506842,0.0000243687,0.0000102598,0.00001709824,0.00001896301,0.00005170967,0.9982113,0.00004264183,0.00001899767,0.0009517869],"study_design_scores_gemma":[0.00002579143,0.001171462,0.01803438,0.00001250496,0.00003544067,0.0003559779,0.0000620767,0.001496506,0.9780521,0.00006518674,0.0006835588,0.000005071635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998027,0.0003010922,0.0008783311,0.00001427746,0.000008494197,0.00001178338,0.00006806828,0.00001149409,0.0006794635],"genre_scores_gemma":[0.9973741,0.0001643432,0.001026215,0.00007556987,0.000009515297,0.00002014081,0.0004123562,0.00001034251,0.0009075708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223488,"threshold_uncertainty_score":0.004092932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443357038737107,"score_gpt":0.2475113739447813,"score_spread":0.2330778035574102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}