{"id":"W2146947580","doi":"10.1242/jcs.080762","title":"Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress","year":2011,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":597,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Parkinson's UK","keywords":"Unfolded protein response; Biology; Cell biology; Mitochondrion; Endoplasmic reticulum; Bioenergetics; Organelle; Programmed cell death; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582172,0.000105899,0.0001486094,0.000102117,0.00010332,0.0000421503,0.0002398811,0.00006003393,0.00001352119],"category_scores_gemma":[0.000248607,0.00008492927,0.00006919066,0.0001256453,0.0003538298,0.00003217049,0.0000773989,0.00007357547,2.667865e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009232503,"about_ca_system_score_gemma":0.0002074136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003651954,"about_ca_topic_score_gemma":0.000007474672,"domain_scores_codex":[0.998916,0.00002211519,0.000357199,0.0001974448,0.0003244705,0.0001827965],"domain_scores_gemma":[0.9989504,0.00001403449,0.0003902241,0.0001632655,0.0002971179,0.0001849617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003847,0.0001277515,0.007114155,0.00002613731,0.000008098821,0.00001029388,0.0001144188,0.00008391645,0.992036,0.00001310948,0.00001487239,0.0000665754],"study_design_scores_gemma":[0.001140832,0.0005846634,0.008870441,0.00005395374,0.00003377492,0.00001504758,0.00006728306,0.0001680517,0.9888996,0.0000377026,0.00002927492,0.00009936944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985686,0.000353556,0.0003741038,0.000008235415,0.0003300493,0.00008589153,0.00001192377,0.000002111147,0.0002655328],"genre_scores_gemma":[0.9963056,0.000115733,0.003207678,0.000008211271,0.0003200654,0.00000144782,0.000001710108,0.000007067177,0.00003241839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003136365,"threshold_uncertainty_score":0.3463315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228673855183869,"score_gpt":0.2385626926074917,"score_spread":0.226275954055653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}