{"id":"W2146966993","doi":"10.1093/rheumatology/keu415","title":"Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA: a systematic review of the literature","year":2014,"lang":"en","type":"review","venue":"Lara D. Veeken","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Medicine; Concomitant; Combination therapy; TNF inhibitor; Observational study; Internal medicine; Randomized controlled trial; Tumor necrosis factor alpha; Oncology; Adalimumab","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":0,"stratum":"about_only","weight":3321.24,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Systematic review comparing TNF inhibitor monotherapy with combination therapy in psoriatic arthritis; uses synthesis to answer a clinical question."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"It synthesizes clinical evidence about psoriasis arthritis treatment, not evidence-synthesis methodology."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Clinical systematic review of TNF inhibitors for PsA; synthesis answers a treatment question."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007614614,0.001264199,0.007440449,0.008807003,0.0004593808,0.001943954,0.001311685,0.001762416,0.00356545],"category_scores_gemma":[0.02476594,0.0009171282,0.005819819,0.008772352,0.0005790543,0.001819589,0.0008517056,0.00085122,0.0003134341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002913914,"about_ca_system_score_gemma":0.008176274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004812075,"about_ca_topic_score_gemma":0.01689729,"domain_scores_codex":[0.9931972,0.002735019,0.002550938,0.0004300379,0.000914712,0.0001721707],"domain_scores_gemma":[0.9764944,0.01565539,0.005584339,0.0002470079,0.001755819,0.0002631282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003535056,0.00002131869,0.0006847326,0.9525771,0.01068429,0.0001097767,0.00009809207,0.00007604389,0.0001961651,0.0001165704,0.0009832921,0.03409908],"study_design_scores_gemma":[0.000651986,0.0006198086,0.005240359,0.8616898,0.1143967,0.0006982858,0.0002853109,0.0001197906,0.0002259706,0.0002427148,0.01578897,0.00004022092],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007255008,0.9987246,0.00005294926,0.000123253,0.00006384653,0.0001158062,0.00008480584,0.000002713787,0.0001063755],"genre_scores_gemma":[0.01184286,0.9867058,0.0004889586,0.0003814943,0.0000958797,0.000309523,0.0001007143,0.00000239051,0.00007238457],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008807003,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017711651867998,"score_gpt":0.304321164809998,"score_spread":0.284144048291318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}