{"id":"W2146987518","doi":"10.1371/journal.pone.0022031","title":"Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; University of California, San Diego; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Wellcome Trust; Ludwig Institute for Cancer Research; Muscular Dystrophy Association; National Institutes of Health; National Science Foundation","keywords":"SOD1; Mitochondrion; Cell biology; Amyotrophic lateral sclerosis; Biology; Motor neuron; Mutant; Superoxide dismutase; Dismutase; Cytoplasm; Neuroscience; Biochemistry; Pathology; Spinal cord; Oxidative stress; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002400238,0.0002306812,0.000570591,0.00007370558,0.0001123593,0.0000395751,0.000161546,0.000208905,0.0003566501],"category_scores_gemma":[0.001495006,0.0001792244,0.00008441627,0.0002578518,0.0001857411,0.0001113008,0.0001223357,0.0004837162,0.0001146201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465301,"about_ca_system_score_gemma":0.0001233695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008922625,"about_ca_topic_score_gemma":0.00003642356,"domain_scores_codex":[0.997417,0.0002230166,0.0004673793,0.0005878258,0.0007660827,0.0005386917],"domain_scores_gemma":[0.9983431,0.0001932547,0.0001207053,0.0004056242,0.000259483,0.0006778936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02073839,0.01172536,0.3961411,0.0002246276,0.002097022,0.0002720671,0.0009768277,2.770407e-7,0.5552,0.000023973,0.00853886,0.004061459],"study_design_scores_gemma":[0.004631921,0.004509828,0.9836181,0.0005524628,0.0003502301,0.000006494382,0.00001352897,0.000459437,0.005513853,0.00001812867,0.00008998979,0.0002359975],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961534,0.00002457949,0.00004262292,0.001668071,0.0001216744,0.001650949,0.0001265125,0.0001159703,0.00009625162],"genre_scores_gemma":[0.9945766,0.00006107133,0.003009772,0.0005573043,0.0004051643,0.0001154486,0.0001830194,0.00005207258,0.001039536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.587477,"threshold_uncertainty_score":0.730856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187185952108911,"score_gpt":0.3011617683318027,"score_spread":0.1824431731209115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}