{"id":"W2147009888","doi":"10.1189/jlb.0404242","title":"Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms","year":2004,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Institute of Genetics; National Institute of General Medical Sciences","keywords":"HMGB1; CD14; MAPK/ERK pathway; Tumor necrosis factor alpha; Lipopolysaccharide; p38 mitogen-activated protein kinases; Biology; Proinflammatory cytokine; TLR4; Kinase; Protein kinase A; Cell biology; Extracellular; Cytokine; Signal transduction; Molecular biology; Immunology; Inflammation; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003212547,0.0001728522,0.0002657235,0.00008332536,0.00007985353,0.00002564371,0.0002531421,0.0001611054,0.00005061096],"category_scores_gemma":[0.0004385691,0.0001418424,0.00007248315,0.00008406994,0.0001015471,0.00001575243,0.0001711441,0.000190408,0.0000156213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005752817,"about_ca_system_score_gemma":0.0002046606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000139458,"about_ca_topic_score_gemma":0.00001204714,"domain_scores_codex":[0.9986948,0.0001305176,0.0004006742,0.0003135783,0.0001408317,0.0003196501],"domain_scores_gemma":[0.9990792,0.00003124476,0.0002184758,0.0002487673,0.0002401891,0.0001820792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007926273,0.00005517804,0.00005383535,0.00001069178,0.00006627577,0.00003977944,0.00006602528,0.001441006,0.9929634,0.0007462435,0.0001607883,0.003604148],"study_design_scores_gemma":[0.001743346,0.001762963,0.0001682485,0.00001531466,0.00001594666,0.0004092508,0.00006608875,0.0000025332,0.9633079,0.005454804,0.02689273,0.000160929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703603,0.001506856,0.02616856,0.001220825,0.0004329151,0.0001983118,0.00002876274,0.000006760815,0.00007674041],"genre_scores_gemma":[0.9828864,0.001033367,0.01451279,0.0004287302,0.000828431,0.000006773922,0.00002411798,0.00002288316,0.000256503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02965556,"threshold_uncertainty_score":0.5784165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01759458617159039,"score_gpt":0.3171266437761986,"score_spread":0.2995320576046083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}