{"id":"W2147013899","doi":"10.1126/scisignal.2000482","title":"Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs","year":2010,"lang":"en","type":"article","venue":"Science Signaling","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":369,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; Howard Hughes Medical Institute","keywords":"Phosphorylation; Yeast; Kinase; Biology; Protein kinase A; Computational biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002030655,0.0002441665,0.0002235796,0.0003663048,0.0001539566,0.0003034333,0.0001857859,0.0001482961,0.0004255962],"category_scores_gemma":[0.0003742619,0.0001185757,0.0001746994,0.000361668,0.000148626,0.0002338728,0.0001517157,0.0003478248,0.0001828289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114119,"about_ca_system_score_gemma":0.0001408106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000632863,"about_ca_topic_score_gemma":0.001374216,"domain_scores_codex":[0.9999452,0.000009174169,0.000005654252,0.0000172499,0.00001527117,0.000007508318],"domain_scores_gemma":[0.9998512,0.00006385111,0.0000367413,0.00001807073,0.0000153632,0.00001477015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003024869,0.00003734479,0.0054224,0.000150126,0.00003383087,0.0001666164,0.00003954954,0.002730383,0.9767617,0.0004188911,0.000142364,0.01379428],"study_design_scores_gemma":[0.00006436256,0.0002266435,0.06327504,0.00001943293,0.0001315445,0.0007783442,0.0001747433,0.06382167,0.8616279,0.002518096,0.007322405,0.00003976024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855655,0.001043837,0.01210882,0.0000572242,0.000009045421,0.00002091624,0.000674432,0.0001446408,0.000375576],"genre_scores_gemma":[0.9775954,0.0008909365,0.01970564,0.00002829773,0.000006973933,0.00001418169,0.001508859,0.00003014514,0.0002195756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000632863,"threshold_uncertainty_score":0.001533926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124175974168915,"score_gpt":0.2800582730532013,"score_spread":0.2676406756363098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}