{"id":"W2147026827","doi":"10.1146/annurev.immunol.20.081501.130710","title":"Negative Regulation of Immunoreceptor Signaling","year":2002,"lang":"en","type":"review","venue":"Annual Review of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Biology; Immunoreceptor tyrosine-based activation motif; Protein tyrosine phosphatase; Signal transduction; Cell biology; Signal transducing adaptor protein; Phosphorylation; Receptor; Receptor tyrosine kinase; Kinase; Tyrosine phosphorylation; Tyrosine; Biochemistry; SH2 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005526225,0.0005623655,0.003672547,0.0004277978,0.00009065475,0.00000374094,0.0005509894,0.000872778,0.0121626],"category_scores_gemma":[0.000734974,0.0004569541,0.001252115,0.0005483896,0.0004724651,0.0001908572,0.0001684148,0.0008741055,0.001618509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138881,"about_ca_system_score_gemma":0.0001681094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005901878,"about_ca_topic_score_gemma":5.532509e-7,"domain_scores_codex":[0.9953644,0.001291381,0.002441773,0.0004520896,0.00007731303,0.0003730747],"domain_scores_gemma":[0.9949669,0.0006928053,0.002926187,0.0007556374,0.0006445696,0.00001386224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004406167,0.0001696581,2.749693e-7,0.0544386,0.001573048,6.233591e-7,0.0001808264,1.016869e-7,0.002342195,0.0004055795,0.01671284,0.9241322],"study_design_scores_gemma":[0.0002953587,0.0004012861,0.000003147298,0.1058156,0.001024197,0.0001253693,0.0001089988,7.55874e-8,0.002673155,0.00001231599,0.8892445,0.0002960291],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004555249,0.9924659,0.00002456464,0.00002752219,0.003528967,0.0009610254,0.00008851715,0.00004239977,0.002856522],"genre_scores_gemma":[0.00003090614,0.9905618,0.00005990111,0.00007206966,0.00003952219,0.00009079139,0.000974725,0.00005513808,0.008115135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9238362,"threshold_uncertainty_score":0.9997882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02290467914918696,"score_gpt":0.2958332528230033,"score_spread":0.2729285736738163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}