{"id":"W2147028601","doi":"10.1056/nejmoa1100391","title":"Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis","year":2011,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":1115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"NHLBI Division of Intramural Research; National Center for Research Resources; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Cincinnati Children's Hospital Medical Center; National Institutes of Health; U.S. Food and Drug Administration; Tuberous Sclerosis Alliance; LAM Foundation; Pfizer","keywords":"Lymphangioleiomyomatosis; Sirolimus; Medicine; Placebo; Lung; Urology; Internal medicine; Vital capacity; Discontinuation; Gastroenterology; Diffusing capacity; Lung function; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002158778,0.000445291,0.00163929,0.0002469047,0.000189306,0.0004275462,0.0003759699,0.0008899266,0.001197679],"category_scores_gemma":[0.002235373,0.0001634366,0.0008465967,0.0002227391,0.0004665818,0.0003749546,0.0002416107,0.001178217,0.0002073971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004028397,"about_ca_system_score_gemma":0.0003423404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857648,"about_ca_topic_score_gemma":0.0002646851,"domain_scores_codex":[0.9988695,0.0006436291,0.0001292873,0.0001077192,0.0001650229,0.00008481701],"domain_scores_gemma":[0.9982496,0.0007512425,0.0005837564,0.00005647585,0.00009758971,0.0002613734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6914803,0.007916288,0.02328052,0.002227018,0.001820533,0.0004817622,0.0002308522,0.002287267,0.04958861,0.0002135946,0.001041092,0.2194321],"study_design_scores_gemma":[0.3207209,0.5603768,0.09874029,0.0002961541,0.001747999,0.001163259,0.00009206883,0.002117476,0.01088412,0.0002338165,0.003588236,0.00003896028],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888012,0.009798018,0.0001963346,0.0002110124,0.00004433179,0.000171274,0.0001066052,0.00001568811,0.0006555379],"genre_scores_gemma":[0.997465,0.001561978,0.0002223802,0.000151313,0.000127391,0.000161261,0.0001637802,0.000002989532,0.0001439093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158778,"threshold_uncertainty_score":0.01141685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07152300693686296,"score_gpt":0.3049537802859522,"score_spread":0.2334307733490892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}