{"id":"W2147028601","doi":"10.1056/nejmoa1100391","title":"Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis","year":2011,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":1115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"NHLBI Division of Intramural Research; National Center for Research Resources; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Cincinnati Children's Hospital Medical Center; National Institutes of Health; U.S. Food and Drug Administration; Tuberous Sclerosis Alliance; LAM Foundation; Pfizer","keywords":"Lymphangioleiomyomatosis; Sirolimus; Medicine; Placebo; Lung; Urology; Internal medicine; Vital capacity; Discontinuation; Gastroenterology; Diffusing capacity; Lung function; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001144334,0.0001195172,0.0006409072,0.0004841693,0.00001759126,0.000002005134,0.0001248266,0.00005989571,0.0003466752],"category_scores_gemma":[0.0005902413,0.00007725219,0.00005096196,0.0003012431,0.0002003995,0.00006027039,0.00003894381,0.000227955,0.000002073175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000455097,"about_ca_system_score_gemma":0.000143756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003082274,"about_ca_topic_score_gemma":0.00002886493,"domain_scores_codex":[0.9983649,0.0001020317,0.0007013372,0.0001117939,0.0005016803,0.0002182364],"domain_scores_gemma":[0.9987575,0.0003081759,0.0002330242,0.0001755017,0.0001691381,0.0003566529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01954868,0.0007226731,0.4333956,0.0003242547,0.0003522753,0.0008260204,0.01347107,0.000007026426,0.06830937,0.0006946793,0.002472489,0.4598759],"study_design_scores_gemma":[0.1131609,0.003354491,0.8741375,0.001514699,0.0001368276,0.002151497,0.0002453824,0.00003193594,0.002303496,0.0003589009,0.002526677,0.00007775029],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914331,0.002390704,0.0001547872,0.002314333,0.0001154461,0.0001666736,8.272098e-7,0.00000598311,0.00341811],"genre_scores_gemma":[0.996934,0.0009503764,0.001190633,0.0001896783,0.0006420516,5.441526e-7,0.000001002281,0.00001495722,0.00007676314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4597981,"threshold_uncertainty_score":0.379585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07152300693686296,"score_gpt":0.3049537802859522,"score_spread":0.2334307733490892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}