{"id":"W2147046090","doi":"10.1186/1742-4690-11-15","title":"HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Université de Montréal; McGill University Health Centre; Royal Victoria Regional Health Centre; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Virology; Antibody; Biology; Immune system; Tetherin; Cell biology; Virus; Cell; Viral envelope; Immunology; Monoclonal antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951835,0.0002338643,0.0005290075,0.000138763,0.0001368309,0.00001180674,0.0001180966,0.0004600022,0.0004294993],"category_scores_gemma":[0.0001337874,0.0001934819,0.00006723289,0.0001472422,0.000460671,0.00008771416,0.000120406,0.0003085936,0.0005663317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002712721,"about_ca_system_score_gemma":0.00003798098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006169202,"about_ca_topic_score_gemma":0.00004207686,"domain_scores_codex":[0.9980827,0.0005951273,0.0003222842,0.0004913869,0.00005535195,0.0004531231],"domain_scores_gemma":[0.998841,0.0005132014,0.000179778,0.0003488306,0.00006429142,0.00005286469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000296892,0.0001576491,0.09974814,0.0000319868,0.0002002808,0.000006981486,0.0002800258,0.000004716901,0.8973298,0.00007851977,0.0004769721,0.001388006],"study_design_scores_gemma":[0.008926253,0.002419589,0.615703,0.00002890064,0.0002390673,0.00003246521,0.00006948401,0.000271473,0.3543227,0.0009196712,0.01664795,0.0004194531],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954538,0.001620598,0.001004238,0.0003380857,0.0001048913,0.0004445636,0.0003614482,0.00005684733,0.0006154684],"genre_scores_gemma":[0.9968227,0.0005572428,0.0003777429,0.00007036235,0.00003355708,0.00002644263,0.001759377,0.0000197653,0.0003328398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5430071,"threshold_uncertainty_score":0.7889962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005873977137636515,"score_gpt":0.2262516645814145,"score_spread":0.220377687443778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}